M-decay: degradation of maternal mRNAs by maternally stored factors

Jiang ZY, Fan HY. Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?†. Biol Reprod. 2022 Jul 25;107(1):62–75. doi: 10.1093/biolre/ioac014. PMID: 35098307.; Zhang JM, Hou WB, Du JW, Zong M, Zheng KL, Wang WJ, Wang JQ, Zhang H, Mu YS, Yin Z, Ding CM, Sun QY, Liu ZH, Kong QR. Argonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos. Cell Death Discov. 2020 Nov 27;6(1):133. PMID: 33298889; PMCID: PMC7691497.; Sha Q, Zheng W, Wu Y, Li S, Guo L, Zhang S, Lin G, Ou X, Fan H. Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans. Nature Communications. 2020 Oct 01;11(1):4917. doi: 10.1038/s41467-020-18680-6.; Zhao LW, Zhu YZ, Chen H, Wu YW, Pi SB, Chen L, Shen L, Fan HY. PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition. EMBO Rep. 2020 Aug 05;21(8):e49956. PMID: 32558204; PMCID: PMC7403729.; Sha Q, Yu J, Guo J, Dai X, Jiang J, Zhang Y, Yu C, Ji S, Jiang Y, Zhang S, Shen L, Ou X, Fan H. CNOT 6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. The EMBO Journal. 2018 Nov 26;37(24). doi: 10.15252/embj.201899333.; Chousal JN, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H. Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Developmental Cell. 2018 Feb;44(3):392–402.e7. doi: 10.1016/j.devcel.2018.01.006.; Pasternak M, Pfender S, Santhanam B, Schuh M. The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs. Open Biol. 2016 Sep;6(9). PMID: 27605379; PMCID: PMC5043581.; Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. J Mol Cell Biol. 2016 Aug;8(4):366–8. doi: 10.1093/jmcb/mjw023. PMID: 27190313.; Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol. 2016 May;23(5):387–94. doi: 10.1038/nsmb.3204. PMID: 27065194.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
3.1.26.n2
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
3.1.13.4 poly(A)-specific ribonuclease
3.1.26.3 ribonuclease III


Proteins

Protein ID name full name