Cobalamin (Cbl) metabolism

Banerjee R, Gouda H, Pillay S. Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking. Acc. Chem. Res. 2021 Apr 02;54(8):2003–13. doi: 10.1021/acs.accounts.1c00083.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Hydrogen cyanide

Formula: CHN (27.010898599999997)

CAS ID: 74-90-8

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Adenosylcobalamin

Formula: C72H101CoN18O17P (1579.6661325999999)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.16.1.8 [methionine synthase] reductase [methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase
2.1.1.13 methionine synthase 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase


Proteins

Protein ID name full name