Diseases of mitotic cell cycle

Sarek G, Marzec P, Margalef P, Boulton SJ. Molecular basis of telomere dysfunction in human genetic diseases. Nature Structural & Molecular Biology. 2015 Nov 04;22(11):867–74. doi: 10.1038/nsmb.3093.; Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A, Cascante M. Targeting cell cycle regulation in cancer therapy. Pharmacol Ther. 2013 May;138(2):255–71. doi: 10.1016/j.pharmthera.2013.01.011. PMID: 23356980.; Webber KM, Raina AK, Marlatt MW, Zhu X, Prat MI, Morelli L, Casadesus G, Perry G, Smith MA. The cell cycle in Alzheimer disease: A unique target for neuropharmacology. Mechanisms of Ageing and Development. 2005 Oct;126(10):1019–25. doi: 10.1016/j.mad.2005.03.024.; Collins I, Garrett MD. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol. 2005 Aug;5(4):366–73. doi: 10.1016/j.coph.2005.04.009. PMID: 15964238.; Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer. 2002 Dec;2(12):910–7. doi: 10.1038/nrc950. PMID: 12459729.

Metabolites



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
3.6.4.12 DNA helicase


Proteins

Protein ID name full name