Cellular response to starvation
Zhuang Y, Wang XX, He J, He S, Yin Y. Recent advances in understanding of amino acid signaling to mTORC1 activation. Front Biosci (Landmark Ed). 2019 Mar 01;24(5):971–82. doi: 10.2741/4762. PMID: 30844724.; Kim J, Guan KL. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 Jan;21(1):63–71. doi: 10.1038/s41556-018-0205-1. PMID: 30602761.; Wek RC. Role of eIF2a Kinases in Translational Control and Adaptation to Cellular Stress. Cold Spring Harb Perspect Biol. 2018 Feb 12;10(7):a032870. doi: 10.1101/cshperspect.a032870.; Meng D, Frank AR, Jewell JL. mTOR signaling in stem and progenitor cells. Development. 2018 Jan 08;145(1). PMID: 29311260; PMCID: PMC5825873.; Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature. 2017 Dec 21;552(7685):368–73. PMID: 29236692; PMCID: PMC5750076.; Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN. Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells. Trends in Endocrinology & Metabolism. 2017 Nov;28(11):794–806. doi: 10.1016/j.tem.2017.07.003.; Sabatini DM. Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proc Natl Acad Sci U S A. 2017 Nov 07;114(45):11818–25. PMID: 29078414; PMCID: PMC5692607.; Wolfson RL, Sabatini DM. The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metabolism. 2017 Aug;26(2):301–9. doi: 10.1016/j.cmet.2017.07.001.; Yao Y, Jones E, Inoki K. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells. Biomolecules. 2017 Jul 07;7(3). PMID: 28686218; PMCID: PMC5618232.; Bröer S, Bröer A. Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem J. 2017 May 25;474(12):1935–63. PMID: 28546457; PMCID: PMC5444488.; Castilho BA, Shanmugam R, Silva RC, Ramesh R, Himme BM, Sattlegger E. Keeping the eIF2 alpha kinase Gcn2 in check. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2014 Sep;1843(9):1948–68. doi: 10.1016/j.bbamcr.2014.04.006.; Demetriades C, Doumpas N, Teleman AA. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014 Feb 13;156(4):786–99. PMID: 24529380; PMCID: PMC4346203.; Gallinetti J, Harputlugil E, Mitchell JR. Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J. 2013 Jan 01;449(1):1–10. PMID: 23216249; PMCID: PMC3695616.; Kilberg MS, Balasubramanian M, Fu L, Shan J. The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells. Advances in Nutrition. 2012 May;3(3):295–306. doi: 10.3945/an.112.001891.; Chaveroux C, Lambert-Langlais S, Cherasse Y, Averous J, Parry L, Carraro V, Jousse C, Maurin AC, Bruhat A, Fafournoux P. Molecular mechanisms involved in the adaptation to amino acid limitation in mammals. Biochimie. 2010 Jul;92(7):736–45. doi: 10.1016/j.biochi.2010.02.020. PMID: 20188139.; Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J. The Rheb Switch 2 Segment Is Critical for Signaling to Target of Rapamycin Complex 1. Journal of Biological Chemistry. 2007 Jun;282(25):18542–51. doi: 10.1074/jbc.m610736200.; Tee AR, Blenis J, Proud CG. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005 Aug 29;579(21):4763–8. doi: 10.1016/j.febslet.2005.07.054. PMID: 16098514.; Long X, Ortiz-Vega S, Lin Y, Avruch J. Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency. Journal of Biological Chemistry. 2005 Jun;280(25):23433–6. doi: 10.1074/jbc.c500169200.; Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol. 2005 Apr 26;15(8):702–13. doi: 10.1016/j.cub.2005.02.053. PMID: 15854902.; Dever TE, Hinnebusch AG. GCN2 whets the appetite for amino acids. Mol Cell. 2005 Apr 15;18(2):141–2. doi: 10.1016/j.molcel.2005.03.023. PMID: 15837415.