Induction of Cell-Cell Fusion
Rajah MM, Bernier A, Buchrieser J, Schwartz O. The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation. Journal of Molecular Biology. 2022 Mar;434(6):167280. doi: 10.1016/j.jmb.2021.167280.; Rajah MM, Hubert M, Bishop E, Saunders N, Robinot R, Grzelak L, Planas D, Dufloo J, Gellenoncourt S, Bongers A, Zivaljic M, Planchais C, Guivel-Benhassine F, Porrot F, Mouquet H, Chakrabarti LA, Buchrieser J, Schwartz O. SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation. EMBO J. 2021 Dec 15;40(24):e108944. PMID: 34601723; PMCID: PMC8646911.; Cheng YW, Chao TL, Li CL, Wang SH, Kao HC, Tsai YM, Wang HY, Hsieh CL, Lin YY, Chen PJ, Chang SY, Yeh SH. D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage. mBio. 2021 Aug 31;12(4):e0058721. PMID: 34311586; PMCID: PMC8406174.; Rey F. Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern. C R Biol. 2021 Jun 21;344(1):77–110. doi: 10.5802/crbiol.53. PMID: 34213849.; Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, Tavares AH, Saeed M, Holehouse AS, Ploss A, Levental I, Douam F, Padera RF, Levy BD, Brangwynne CP. Author response: SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. 2021 Mar 31;(). doi: 10.7554/elife.65962.sa2.; Zhang Z, Zheng Y, Niu Z, Zhang B, Wang C, Yao X, Peng H, Franca DN, Wang Y, Zhu Y, Su Y, Tang M, Jiang X, Ren H, He M, Wang Y, Gao L, Zhao P, Shi H, Chen Z, Wang X, Piacentini M, Bian X, Melino G, Liu L, Huang H, Sun Q. SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination. Cell Death & Differentiation. 2021 Apr 20;28(9):2765–77. doi: 10.1038/s41418-021-00782-3.; Buchrieser J, Dufloo J, Hubert M, Monel B, Planas D, Rajah MM, Planchais C, Porrot F, Guivel-Benhassine F, Van der Werf S, Casartelli N, Mouquet H, Bruel T, Schwartz O. Syncytia formation by SARS-CoV-2-infected cells. EMBO J. 2020 Dec 01;39(23):e106267. PMID: 33051876; PMCID: PMC7646020.; Hoffmann M, Kleine-Weber H, Pöhlmann S. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. Molecular Cell. 2020 May;78(4):779–784.e5. doi: 10.1016/j.molcel.2020.04.022.; Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Research. 2020 Mar 30;30(4):343–55. doi: 10.1038/s41422-020-0305-x.; Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, Guo L, Guo R, Chen T, Hu J, Xiang Z, Mu Z, Chen X, Chen J, Hu K, Jin Q, Wang J, Qian Z. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nature Communications. 2020 Mar 27;11(1):1620. doi: 10.1038/s41467-020-15562-9.