Protein hydroxylation

Herr CQ, Hausinger RP. Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases. Trends in Biochemical Sciences. 2018 Jul;43(7):517–32. doi: 10.1016/j.tibs.2018.04.002.; Zurlo G, Guo J, Takada M, Wei W, Zhang Q. New Insights into Protein Hydroxylation and Its Important Role in Human Diseases. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2016 Dec;1866(2):208–20. doi: 10.1016/j.bbcan.2016.09.004.; Stoehr A, Yang Y, Patel S, Evangelista AM, Aponte A, Wang G, Liu P, Boylston J, Kloner PH, Lin Y, Gucek M, Zhu J, Murphy E. Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res. 2016 Jun 01;110(3):346–58. PMID: 27095734; PMCID: PMC4872881.; Markolovic S, Wilkins SE, Schofield CJ. Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases. Journal of Biological Chemistry. 2015 Aug;290(34):20712–22. doi: 10.1074/jbc.r115.662627.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4



Enzyme

EC Number name full name note
1.14.11.-
1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase [histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase
1.14.11.73 [protein]-arginine 3-hydroxylase [protein]-L-arginine,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating)
1.14.11.79 protein-L-histidine (3S)-3-hydroxylase protein-L-histidine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)


Proteins

Protein ID name full name