RHOA GTPase cycle

Müller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P, Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP, Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E, Rocks O. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nat Cell Biol. 2020 Apr;22(4):498–511. doi: 10.1038/s41556-020-0488-x. PMID: 32203420.; Bros M, Haas K, Moll L, Grabbe S. RhoA as a Key Regulator of Innate and Adaptive Immunity. Cells. 2019 Jul 17;8(7). PMID: 31319592; PMCID: PMC6678964.; Jamilloux Y, Magnotti F, Belot A, Henry T. The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes. Pathog Dis. 2018 Apr 01;76(3). doi: 10.1093/femspd/fty020. PMID: 29718184.; Hu J, Selzer ME. RhoA as a target to promote neuronal survival and axon regeneration. Neural Regen Res. 2017 Apr;12(4):525–8. PMID: 28553321; PMCID: PMC5436339.; Kataoka K, Ogawa S. Variegated RHOA mutations in human cancers. Exp Hematol. 2016 Dec;44(12):1123–9. doi: 10.1016/j.exphem.2016.09.002. PMID: 27693615.; Ricker E, Chowdhury L, Yi W, Pernis AB. The RhoA-ROCK pathway in the regulation of T and B cell responses. F1000Res. 2016 Sep 12;5():2295. doi: 10.12688/f1000research.7522.1.; Shimokawa H, Sunamura S, Satoh K. RhoA/Rho-Kinase in the Cardiovascular System. Circ Res. 2016 Jan 22;118(2):352–66. doi: 10.1161/circresaha.115.306532. PMID: 26838319.; Cai A, Li L, Zhou Y. Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system. J Hypertens. 2016 Jan;34(1):3–10. doi: 10.1097/hjh.0000000000000768. PMID: 26556565.; Fujita Y, Yamashita T. Axon growth inhibition by RhoA/ROCK in the central nervous system. Front. Neurosci. 2014 Oct 22;8(). doi: 10.3389/fnins.2014.00338.; Marjoram RJ, Lessey EC, Burridge K. Regulation of RhoA activity by adhesion molecules and mechanotransduction. Curr Mol Med. 2014 Feb;14(2):199–208. PMID: 24467208; PMCID: PMC3929014.; Zhou X, Zheng Y. Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting. Journal of Biological Chemistry. 2013 Dec;288(51):36179–88. doi: 10.1074/jbc.r113.515486.; Lessey EC, Guilluy C, Burridge K. From mechanical force to RhoA activation. Biochemistry. 2012 Sep 25;51(38):7420–32. PMID: 22931484; PMCID: PMC3567302.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name