FLT3 signaling through SRC family kinases
Kazi JU, Rönnstrand L. FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications. Physiol Rev. 2019 Jul 01;99(3):1433–66. doi: 10.1152/physrev.00029.2018. PMID: 31066629.; Kazi JU, Rönnstrand L. The role of SRC family kinases in FLT3 signaling. The International Journal of Biochemistry & Cell Biology. 2019 Feb;107():32–7. doi: 10.1016/j.biocel.2018.12.007.; Marhäll A, Kazi JU, Rönnstrand L. The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation. Scientific Reports. 2017 Oct 23;7(1):13734. doi: 10.1038/s41598-017-14033-4.; Chougule RA, Kazi JU, Rönnstrand L. FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia. Oncotarget. 2016 Mar 01;7(9):9964–74. PMID: 26848862; PMCID: PMC4891096.; Puissant A, Fenouille N, Alexe G, Pikman Y, Bassil CF, Mehta S, Du J, Kazi JU, Luciano F, Rönnstrand L, Kung AL, Aster JC, Galinsky I, Stone RM, DeAngelo DJ, Hemann MT, Stegmaier K. SYK is a critical regulator of FLT3 in acute myeloid leukemia. Cancer Cell. 2014 Feb 10;25(2):226–42. PMID: 24525236; PMCID: PMC4106711.; Mitina O, Warmuth M, Krause G, Hallek M, Obermeier A. Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner. Ann Hematol. 2007 Nov;86(11):777–85. doi: 10.1007/s00277-007-0344-0. PMID: 17668209.; Heiss E, Masson K, Sundberg C, Pedersen M, Sun J, Bengtsson S, Rönnstrand L. Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Blood. 2006 Sep 01;108(5):1542–50. doi: 10.1182/blood-2005-07-008896. PMID: 16684964.; Dosil M, Wang S, Lemischka IR. Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells. Molecular and Cellular Biology. 1993 Oct 01;13(10):6572–85. doi: 10.1128/mcb.13.10.6572-6585.1993.