mangrove triterpenoid biosynthesis

Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K. Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae. FEBS J. 2007 Oct;274(19):5028–42. doi: 10.1111/j.1742-4658.2007.06025.x. PMID: 17803686.; Guhling O, Hobl B, Yeats T, Jetter R. Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. Archives of Biochemistry and Biophysics. 2006 Apr;448(1-2):60–72. doi: 10.1016/j.abb.2005.12.013.; Segura MJR, Meyer MM, Matsuda SPT. Arabidopsis thaliana LUP1 Converts Oxidosqualene to Multiple Triterpene Alcohols and a Triterpene Diol. Org. Lett. 2000 Jul 01;2(15):2257–9. doi: 10.1021/ol006016b.; Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y. Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase. Eur J Biochem. 2000 Jun;267(12):3453–60. doi: 10.1046/j.1432-1327.2000.01357.x. PMID: 10848960.; Herrera JB, Bartel B, Wilson WK, Matsuda SP. Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Phytochemistry. 1998 Dec;49(7):1905–11. doi: 10.1016/s0031-9422(98)00366-5. PMID: 9883589.

Metabolites

(S)-2,3-Epoxysqualene

Formula: C30H50O (426.386145)

CAS ID: 54910-48-4

alpha-Amyrin

Formula: C30H50O (426.386145)

CAS ID: 638-95-9

Cycloartenol

Formula: C30H50O (426.386145)

CAS ID: 469-38-5

Lupeol

Formula: C30H50O (426.386145)

CAS ID: 545-47-1

Taraxerol

Formula: C30H50O (426.386145)

CAS ID: 127-22-0



Enzyme

EC Number name full name note
5.4.99.34 germanicol synthase (S)-2,3-epoxysqualene mutase (cyclizing, germanicol-forming)
5.4.99.35 taraxerol synthase (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming)
5.4.99.39 beta-amyrin synthase (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming)
5.4.99.41 lupeol synthase (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming)


Proteins

Protein ID name full name