Napabucasin (BioCAD00000620175)

plant natural products

Metabolite Card

Formula: C14H8O4 (240.0423)
SMILES: CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O

Synonyms [en]

UNII-Z1HHM49K7O; 2-Acetylfuranonaphthoquinone; DPHUWDIXHNQOSY-UHFFFAOYSA-N; Cancer cell stemness inhibitor (Napabucasin); Napabucasin; Z1HHM49K7O

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Napabucasin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000620175). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Napabucasin has been investigated for the treatment of Colorectal Carcinoma. Napabucasin is a natural product found in Ekmanianthe longiflora, Newbouldia laevis, and Handroanthus impetiginosus with data available. Napabucasin is an orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, napabucasin appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 83280-65-3
  • PubChem: 10331844
  • NCBI MeSH: napabucasin
  • DrugBank: DB12155
  • Coconut NaturalProduct: CNP0210195.0
  • Coconut NaturalProduct: CNP0304915.0

Class / Ontology

Metabolic Network
ID EC Number Name
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