Antrafenine (BioCAD00000026368)

blood urine

Metabolite Card

Formula: C30H26F6N4O2 (588.196)
SMILES: FC(F)(F)C1=CC(=CC=C1)N1CCN(CCOC(=O)C2=CC=CC=C2NC2=C3C=CC(=CC3=NC=C2)C(F)(F)F)CC1

Synonyms [en]

Antrafenine; Antrafenine dihydrochloride; 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate; Stakane; 2-(4-(m-trifluoromethyl-phenyl)-1-piperazinyl)ethyl 2-(7-trifluoromethyl-4-quinolinylamino)benzoate; antrafenine hydrochloride

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Antrafenine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000026368). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Antrafenine is only found in individuals that have used or taken this drug. It is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.Antrafenine is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.

Cytoplasm Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 55300-29-3
  • CAS Registry Number: 55300-30-6
  • PubChem: 68723
  • ChEBI: ChEBI:135841
  • ChEBI: ChEBI:354983
  • HMDB: HMDB0015488
  • HMDB: HMDB15488
  • NCBI MeSH: antrafenine
  • Wikipedia: Antrafenine
  • DrugBank: DB01419
  • RefMet: RM0136594
  • MoNA: WA001827
  • MoNA: WA001828
  • MoNA: WA001829
  • MoNA: WA001830
  • MoNA: WA001831
  • MoNA: WA001832
  • Metlin: METLIN_85513

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0000693 Antrafenine Action Pathway
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