dGTP (BioCAD00000009825)

microbial natural products

Metabolite Card

Formula: C10H16N5O13P3 (506.9957)
SMILES: NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1

Synonyms [en]

dGTP; deoxyguanosine triphosphate; 2'-Deoxyguanosine 5'-triphosphate; deoxy-GTP; Deoxyguanosine 5'-triphosphate; 2'-Deoxyguanosine 5'-(tetrahydrogen triphosphate)

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

dGTP. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000009825). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Deoxyguanosine triphosphate (dGTP) is a nucleoside triphosphate, and a nucleotide precursor used in cells for DNA synthesis. dGTP is used in the polymerase chain reaction technique, in sequencing, and in cloning. It is also the competitor of inhibition onset by acyclovir in the treatment of HSV virus. Under normal physiologic conditions, deoxyguanosine (dGuo) undergoes phosphorolysis by purine nucleoside phosphorylase (PNP, EC 2.4.2.1, an enzyme involved in the recycling of nucleosides and deoxynucleosides in cellular remodeling). However, when PNP is inhibited, deoxycytidine kinase (dCK, EC 2.7.1.74) shunts unmetabolized dGuo into deoxyguanosine triphosphate (dGTP), which accumulates and blocks DNA synthesis. Deficiency of purine nucleoside phosphorylase results in defective T-cell immunity. A correlation between the degree of T cell inhibition and the level of dCK activity has been observed. (PMID:11287638, 402573).

Mitochondria Nucleus
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 2564-35-4
  • CAS Registry Number: 93919-41-6
  • PubChem: 135398599
  • PubChem: 65103
  • ChEBI: ChEBI:16497
  • HMDB: HMDB0001440
  • KEGG: C00286
  • NCBI MeSH: deoxyguanosine triphosphate
  • Wikipedia: Deoxyguanosine triphosphate
  • Wikipedia: Deoxyguanosine_triphosphate
  • DrugBank: DB02181
  • RefMet: RM0136101
  • MoNA: EMBL_MCF_2_0_HRMS_Library000273
  • MoNA: MoNA024156
  • MoNA: MoNA024170
  • MoNA: MoNA033949
  • MoNA: MoNA033952
  • MoNA: MoNA033955
  • MoNA: MoNA037844
  • Metlin: METLIN_3588
  • Coconut NaturalProduct: CNP0085560.1
  • Coconut NaturalProduct: CNP0526757.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00376 2.7.7.7 deoxyguanosine 5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
KEGG:R01855 3.6.1.- 2'-deoxyguanosine 5'-triphosphate diphosphohydrolase
KEGG:R01856 3.1.5.1 dGTP triphosphohydrolase
KEGG:R01857 2.7.4.6 ATP:dGDP phosphotransferase
KEGG:R01858 2.7.1.40 dGTP:pyruvate 2-O-phosphotransferase
KEGG:R02020 1.17.4.2 2'-deoxyguanosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
KEGG:R07278 2.6.99.1 dGTP:depurinated-DNA purine transferase
KEGG:R11633 1.1.98.6 GTP:formate 2'-oxidoreductase
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Organism Source

Taxonomy Source

  1. Escherichia coli [ncbi taxid: 562]

Pathway Synthetic

pathway id name
PathBank:SMP0000927 Purine Nucleotides De Novo Biosynthesis
PathBank:SMP0002047 Purine Nucleotides De Novo Biosynthesis 2
PathBank:SMP0120670 Adenylosuccinate Lyase Deficiency
PathBank:SMP0120448 Adenosine Deaminase Deficiency
PathBank:SMP0120452 AICA-Ribosiduria
PathBank:SMP0120508 Lesch-Nyhan Syndrome (LNS)
PathBank:SMP0120532 Molybdenum Cofactor Deficiency
PathBank:SMP0120536 Purine Nucleoside Phosphorylase Deficiency
PathBank:SMP0120577 Xanthinuria Type I
PathBank:SMP0120601 Mitochondrial DNA Depletion Syndrome
PathBank:SMP0000167 Adenylosuccinate Lyase Deficiency
PathBank:SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria)
PathBank:SMP0000512 Xanthinuria Type I
PathBank:SMP0000536 Mitochondrial DNA Depletion Syndrome-3
PathBank:SMP0063668 Purine Metabolism
PathBank:SMP0120669 Adenosine Deaminase Deficiency
PathBank:SMP0120673 AICA-Ribosiduria
PathBank:SMP0120709 Gout or Kelley-Seegmiller Syndrome
PathBank:SMP0120717 Xanthine Dehydrogenase Deficiency (Xanthinuria)
PathBank:SMP0120797 Xanthinuria Type II
View All Pathways