(S)-Corytuberine (BioCAD00000000978)

plant natural products microbial natural products

Metabolite Card

Formula: C19H21NO4 (327.1471)
SMILES: C1=2C=3[C@@](N(CC1)C)(CC4=C(C3C(=C(C2)OC)O)C(=C(C=C4)OC)O)[H]

Synonyms [en]

(S)-corytuberine; (+)-CORYTUBERINE; corytuberine; 4YJ94A3D8W; UNII-4YJ94A3D8W; (6aS)-2,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

(S)-Corytuberine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000000978). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer)." []

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 517-56-6
  • PubChem: 160500
  • ChEBI: ChEBI:81200
  • KEGG: C17591
  • BioCyc: CPD-9935
  • NCBI MeSH: corytuberine
  • MoNA: PM010812
  • Metlin: METLIN_64383
  • Coconut NaturalProduct: CNP0118754.1
  • Coconut NaturalProduct: CNP0187393.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R08790 1.14.19.51 (S)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling; (S)-corytuberine-forming)
KEGG:R08791 2.1.1.337 S-adenosyl-L-methionine:(S)-corytuberine N-methyltransferase
Rhea:RHEA:51525 2.1.1.337 (S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine
Rhea:RHEA:51526 2.1.1.337 magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine
Rhea:RHEA:51527 2.1.1.337 (S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine
Rhea:RHEA:51541 1.14.19.51 (S)-reticuline + reduced [NADPH—hemoprotein reductase] + O2 => (S)-corytuberine + oxidized [NADPH—hemoprotein reductase] + 2 H2O + 2 H+
Rhea:RHEA:51542 1.14.19.51 (S)-corytuberine + oxidized [NADPH—hemoprotein reductase] + 2 H2O + 2 H+ => (S)-reticuline + reduced [NADPH—hemoprotein reductase] + O2
Rhea:RHEA:51543 1.14.19.51 (S)-reticuline + reduced [NADPH—hemoprotein reductase] + O2 <=> (S)-corytuberine + oxidized [NADPH—hemoprotein reductase] + 2 H2O + 2 H+
BioCyc:RXN-9314 1.14.19.51 S-RETICULINE + Red-NADPH-Hemoprotein-Reductases + OXYGEN-MOLECULE --> CPD-9935 + Ox-NADPH-Hemoprotein-Reductases + 2 WATER
BioCyc:RXN-9315 2.1.1.337 S-ADENOSYLMETHIONINE + CPD-9935 --> ADENOSYL-HOMO-CYS + CPD-9936 + PROTON
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Organism Source

Taxonomy Source

  1. Artabotrys monteiroae [ncbi taxid: 1636225]
  2. Cephalotaxus fortunei [ncbi taxid: 66169]
  3. Elastostema sinuata [ncbi taxid: ]
  4. Miliusa cuneata [ncbi taxid: 235751]
  5. Monodora angolensis [ncbi taxid: 493329]
  6. Aconitum firmum [ncbi taxid: 1496655]
  7. Actaea racemosa [ncbi taxid: 64040]
  8. Actaea spicata L. [ncbi taxid: ]
  9. Aloe microstigma [ncbi taxid: 1128801]
  10. Annona montana [ncbi taxid: 49857]
  11. Aplidium multiplicatum [ncbi taxid: 3106037]
  12. Aristolochia clematitis L. [ncbi taxid: ]
  13. Aristolochia gigantea [ncbi taxid: 12948]
  14. Aristolochia rotunda L. [ncbi taxid: ]
  15. Balaenoptera borealis [ncbi taxid: 9768]
  16. Brickellia paniculata [ncbi taxid: 1550853]
  17. Caulophyllum thalicroides [ncbi taxid: ]
  18. Chrozophora prostrata [ncbi taxid: ]
  19. Cissampelos pareira L. [ncbi taxid: ]
  20. Clematis parviloba [ncbi taxid: 1857144]
  21. Coptis japonica [ncbi taxid: 3442]
  22. Corydalis dasyptera [ncbi taxid: 2182694]
  23. Corydalis gortschakovii [ncbi taxid: 2764626]
  24. Corydalis nobilis [ncbi taxid: 38909]
  25. Corydalis tuberosa [ncbi taxid: ]
  26. Dehaasia triandra [ncbi taxid: ]
  27. Delphinium pentagynum [ncbi taxid: 1127184]
  28. Dilphinium caeruleum [ncbi taxid: ]
  29. Dovyalis hebecarpa [ncbi taxid: 688332]
  30. Eremophila oppositifolia [ncbi taxid: 2652586]
  31. Eschscholzia californica [ncbi taxid: 3467]
  32. Fissistigma oldhamii [ncbi taxid: 453234]
  33. Fumaria capreolata L. [ncbi taxid: ]
  34. Fumaria densiflora [ncbi taxid: 1092452]
  35. Fumaria officinalis L. s.l. [ncbi taxid: ]
  36. Fumaria schleicheri Soy-Will. [ncbi taxid: ]
  37. Glaucium fimbrilligerum Boiss. [ncbi taxid: ]
  38. Guatteria goudotiana [ncbi taxid: ]
  39. Hernandia sonora [ncbi taxid: 482941]
  40. Hydnum aurantiacum [ncbi taxid: ]
  41. Iris decora [ncbi taxid: 585812]
  42. Ixeris repens [ncbi taxid: 520761]
  43. Kolobopetalum auriculatum Engl. [ncbi taxid: ]
  44. Litsea deccanensis [ncbi taxid: 1941426]
  45. Lycopodium chinense [ncbi taxid: ]
  46. Magnolia obovata [ncbi taxid: 349509]
  47. Magnolia officinalis [ncbi taxid: 85864]
  48. Mahonia aquifolium (Pursh) Nutt. [ncbi taxid: ]
  49. Meconopsis cambrica [ncbi taxid: 248829]
  50. Meconopsis robusta [ncbi taxid: 1451204]
  51. Monodora junodii [ncbi taxid: 493334]
  52. Neolitsea konishii [ncbi taxid: 1609886]
  53. Ocotea holdrigeana [ncbi taxid: ]
  54. Oncodostigma monosperma [ncbi taxid: ]
  55. Papaver albiflorum [ncbi taxid: ]
  56. Papaver confine [ncbi taxid: ]
  57. Papaver dubium [ncbi taxid: 357469]
  58. Papaver dubium L. [ncbi taxid: ]
  59. Papaver pinnatifidum [ncbi taxid: ]
  60. Papaver rhoeas [ncbi taxid: 33128]
  61. Papaver rhoeas L. [ncbi taxid: ]
  62. Papaver setigerum [ncbi taxid: ]
  63. Papaver somniferum [ncbi taxid: 3469]
  64. Papaver stevenianum [ncbi taxid: ]
  65. Pedicularis chinensis [ncbi taxid: 399715]
  66. Penicillium vulpinum [ncbi taxid: 29845]
  67. Phoebe minutiflora [ncbi taxid: ]
  68. Platytaenia dasycarpa [ncbi taxid: ]
  69. Pycnarrhena novoguineensis [ncbi taxid: 461620]
  70. Stephania brachyandra Diels [ncbi taxid: ]
  71. Stephania macrantha [ncbi taxid: 1501469]
  72. Stephania micrantha H.S.Lo [ncbi taxid: ]
  73. Stephania officinarum [ncbi taxid: 1501471]
  74. Stylophorum lasiocarpum [ncbi taxid: 72189]
  75. Taxillus yadoriki [ncbi taxid: 2777184]
  76. Thalictrum flavum [ncbi taxid: 150094]
  77. Tinospora cordifolia [ncbi taxid: 285590]
  78. transgenic Escherichia coli + Saccharomyces cerevisiae strains [ncbi taxid: ]
  79. Tylopilus plumbeoviolaceus [ncbi taxid: 182793]
  80. Xylopia parviflora [ncbi taxid: 992813]
  81. Xylopia vieillardi [ncbi taxid: ]
  82. Zizyphus jujuba var. spinosa [ncbi taxid: ]

Pathway Synthetic

pathway id name
PlantCyc:PLANT_PWY-5876 magnoflorine biosynthesis
PlantCyc:NTABACUM_TN90_PWY-5876 magnoflorine biosynthesis
PlantCyc:PAPAYA_PWY-5876 magnoflorine biosynthesis
PlantCyc:CORKOAK_PWY-5876 magnoflorine biosynthesis
PlantCyc:GRAPE_PWY-5876 magnoflorine biosynthesis
PlantCyc:CCAPSULARIS_PWY-5876 magnoflorine biosynthesis
PlantCyc:CASSAVA_PWY-5876 magnoflorine biosynthesis
PlantCyc:POPLAR_PWY-5876 magnoflorine biosynthesis
PlantCyc:RUBBERTREE_PWY-5876 magnoflorine biosynthesis
PlantCyc:VALLEYOAK_PWY-5876 magnoflorine biosynthesis
PlantCyc:MGUTTATUS_PWY-5876 magnoflorine biosynthesis
PlantCyc:ACOERULEA_PWY-5876 magnoflorine biosynthesis
PlantCyc:POTATO_PWY-5876 magnoflorine biosynthesis
PlantCyc:SPENNELLII_PWY-5876 magnoflorine biosynthesis
PlantCyc:SUNFLOWER_PWY-5876 magnoflorine biosynthesis
PlantCyc:TOMATO_PWY-5876 magnoflorine biosynthesis
PlantCyc:OEUROPAEA_SYLVESTRIS_PWY-5876 magnoflorine biosynthesis
PlantCyc:OPUNCTATA_PWY-5876 magnoflorine biosynthesis
PlantCyc:EGGPLANT_PWY-5876 magnoflorine biosynthesis
PlantCyc:EGRANDIS_PWY-5876 magnoflorine biosynthesis
View All Pathways