D-Xylulose (BioCAD00000009477)

blood cerebrospinal fluid (csf) feces urine fibroblasts placenta microbial natural products

Metabolite Card

Formula: C5H10O5 (150.0528)
SMILES: OC[C@@]1(O)OC[C@@H](O)[C@@H]1O

Synonyms [en]

D-Xylulose; D-Threo-pentulose; xylulose; D-Xul; D-Lyxulose; D-Xylulose (0.5 M in Water)

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

D-Xylulose. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000009477). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

D-Xylulose (CAS: 551-84-8) is a monosaccharide containing five carbon atoms. D-Xylulose is converted from xylitol by the enzyme NAD+-linked xylitol dehydrogenase (EC 1.1.1.9) in the glucuronate pathway, the most important xylitol-handling metabolic pathway in mammals. This activity has been described in human erythrocytes. Most likely, D-xylulose (as well as D-arabinose or D-ribulose) is a precursor of the pentiol D-arabitol, since pentitols are derived from their corresponding pentose phosphate precursors via pentoses. This pathway can play a role in inherited metabolic disorders underlying the accumulation of pentitols (e.g. ribose 5-phosphate isomerase deficiency and transaldolase deficiency). Although pentitols are present in all living organisms, knowledge concerning their metabolism is limited (PMID:15234337, Mol Genet Metab. 2004 Jul;82(3):231-7.).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 20750-28-1
  • CAS Registry Number: 551-84-8
  • CAS Registry Number: 5962-29-8
  • PubChem: 12358757
  • PubChem: 3604
  • PubChem: 439204
  • PubChem: 5289590
  • ChEBI: ChEBI:17140
  • HMDB: HMDB0001644
  • KEGG: C00310
  • BioCyc: D-XYLULOSE
  • NCBI MeSH: Xylulose
  • Wikipedia: Xylulose
  • DrugBank: DB03947
  • RefMet: RM0160822
  • MoNA: GLS00177
  • MoNA: HMDB0001644_ms_ms_1666
  • MoNA: HMDB0001644_ms_ms_1667
  • MoNA: HMDB0001644_ms_ms_1668
  • MoNA: KZ000026
  • MoNA: KZ000130
  • MoNA: KZ000131
  • MoNA: OUF00220
  • MoNA: PR010054
  • MoNA: PS022501
  • MoNA: PS022502
  • MoNA: PS022503
  • Metlin: METLIN_63099
  • Coconut NaturalProduct: CNP0266174.4

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01432 5.3.1.5 D-xylose aldose-ketose-isomerase
KEGG:R01639 2.7.1.17 ATP:D-xylulose 5-phosphotransferase
KEGG:R01896 1.1.1.9 xylitol:NAD+ 2-oxidoreductase (D-xylulose-forming)
KEGG:R01898 5.3.1.15 D-lyxose aldose-ketose-isomerase
KEGG:R05604 1.1.1.11 D-arabinitol:NAD 4-oxidoreductase
KEGG:R07143 1.1.1.287 D-arabinitol:NADP+ oxidoreductase
BioCyc:XYLULOKIN-RXN 2.7.1.17 D-XYLULOSE + ATP --> PROTON + XYLULOSE-5-PHOSPHATE + ADP
Rhea:RHEA:10965 2.7.1.17 D-xylulose + ATP => D-xylulose 5-phosphate + ADP + H+
Rhea:RHEA:10966 2.7.1.17 D-xylulose 5-phosphate + ADP + H+ => D-xylulose + ATP
Rhea:RHEA:10967 2.7.1.17 D-xylulose + ATP <=> D-xylulose 5-phosphate + ADP + H+
Rhea:RHEA:14202 5.3.1.15 D-lyxose => D-xylulose
Rhea:RHEA:14203 5.3.1.15 D-xylulose => D-lyxose
Rhea:RHEA:14204 5.3.1.15 D-lyxose <=> D-xylulose
Rhea:RHEA:17922 1.1.1.11 D-arabinitol + NAD+ => D-xylulose + NADH + H+
Rhea:RHEA:17923 1.1.1.11 D-xylulose + NADH + H+ => D-arabinitol + NAD+
Rhea:RHEA:17924 1.1.1.11 D-arabinitol + NAD+ <=> D-xylulose + NADH + H+
Rhea:RHEA:20434 1.1.1.9 xylitol + NAD+ => D-xylulose + NADH + H+
Rhea:RHEA:20435 1.1.1.9 D-xylulose + NADH + H+ => xylitol + NAD+
Rhea:RHEA:20436 1.1.1.9 xylitol + NAD+ <=> D-xylulose + NADH + H+
Rhea:RHEA:21277 1.1.1.287 D-arabinitol + NADP+ => D-xylulose + NADPH + H+
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Organism Source

Taxonomy Source

  1. Escherichia coli [ncbi taxid: 562]
  2. Homo sapiens [ncbi taxid: 9606]
  3. Mus musculus [ncbi taxid: 10090]
  4. Saccharomyces cerevisiae [ncbi taxid: 4932]

Pathway Synthetic

pathway id name
PlantCyc:SOY_LARABITOLUTIL-PWY xylitol degradation
PlantCyc:SOY_XYLCAT-PWY D-xylose degradation I
PlantCyc:ORYZA_XYLCAT-PWY D-xylose degradation I
PlantCyc:ARA_XYLCAT-PWY D-xylose degradation I
WikiPathways:WP3604 Biochemical pathways: part I
View All Pathways