D-Glucono-1,5-lactone 6-phosphate (BioCAD00000009343)

cellular cytoplasm

Metabolite Card

Formula: C6H11O9P (258.0141)
SMILES: O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)OC(=O)[C@@H]1O

Synonyms [en]

D-Glucono-1,5-lactone 6-phosphate; 6-phospho-D-glucono-1,5-lactone; [(2R,3S,4S,5R)-3,4,5-trihydroxy-6-oxotetrahydro-2H-pyran-2-yl]methyl dihydrogen phosphate; delta-Gluconolactone 6-phosphate; 6-phosphonoglucono-delta-lactone; 6-(dihydrogen phosphate)-D-Gluconic acid delta-lactone

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

D-Glucono-1,5-lactone 6-phosphate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000009343). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

6-phosphoglucono-delta-lactone (d-6PGL) is the immediate product of the Glucose-6-phosphate dehydrogenase (G-6-PD), the first enzyme of the hexose monophosphate pathway. (PMID 3711719). The pentose-phosphate pathway provides reductive power and nucleotide precursors to the cell through oxidative and nonoxidative branches. 6-Phosphogluconolactonase is the second enzyme of the oxidative branch and catalyzes the hydrolysis of 6-phosphogluconolactones, the products of glucose 6-phosphate oxidation by glucose-6-phosphate dehydrogenase. By efficiently catalyzing the hydrolysis of d-6PGL, 6-phosphogluconolactonase prevents the reaction between d-6PGL and intracellular nucleophiles; such a reaction would interrupt the functioning of the pentose-phosphate pathway. (PMID 11457850).

Endoplasmic reticulum
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 2641-81-8
  • PubChem: 439452
  • ChEBI: ChEBI:16938
  • HMDB: HMDB0001127
  • KEGG: C01236
  • NCBI MeSH: 6-phosphonoglucono-delta-lactone
  • Wikipedia: 6-Phosphogluconolactone
  • RefMet: RM0013440
  • Metlin: METLIN_3388
  • Coconut NaturalProduct: CNP0359905.1
  • Coconut NaturalProduct: CNP0359905.2

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00835 1.1.1.49 D-glucose-6-phosphate:NADP+ 1-oxidoreductase
KEGG:R02035 3.1.1.31 6-phospho-D-glucono-1,5-lactone lactonohydrolase
KEGG:R02736 1.1.1.49 beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
KEGG:R09550 1.1.98.2 D-glucose-6-phosphate:F420 1-oxidoreductase
KEGG:R10520 1.1.1.363 D-glucose-6-phosphate:NAD+ 1-oxidoreductase
KEGG:R10907 1.1.1.363 beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase
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Organism Source

Taxonomy Source

  1. Escherichia coli [ncbi taxid: 562]

Pathway Synthetic

pathway id name
BioCyc:LEISH_PWY3IU-99 superpathway of central carbon metabolism
BioCyc:LEISH_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch)
BioCyc:TRYPANO_RUMP-PWY formaldehyde oxidation I
BioCyc:TRYPANO_GLYCOLYSIS-E-D superpathway of glycolysis and Entner-Doudoroff
BioCyc:TRYPANO_P122-PWY heterolactic fermentation
BioCyc:TRYPANO_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch)
BioCyc:LEISH_PENTOSE-P-PWY pentose phosphate pathway
BioCyc:TRYPANO_PENTOSE-P-PWY pentose phosphate pathway
WikiPathways:WP282 Pentose phosphate pathway
WikiPathways:WP134 Pentose phosphate metabolism
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP332 RuMP cycle, oxidative branch of the pentose phosphate pathway and formaldehyde assimilation
WikiPathways:WP63 Pentose phosphate pathway
WikiPathways:WP3602 Metabolism overview
WikiPathways:WP2562 Relationship between glutathione and NADPH
WikiPathways:WP379 Pentose pathway, non-oxidative branch
WikiPathways:WP1028 Pentose phosphate pathway
WikiPathways:WP369 Pentose phosphate pathway
WikiPathways:WP1231 Pentose phosphate pathway
PathBank:SMP0087270 Warburg Effect
View All Pathways