Metabolite Card
Formula: C18H19ClN4 (326.1298)
SMILES: CN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12
Synonyms [en]
clozapine; Clozapinum; Clozapin; Clozapine (Clozaril); Clozapina; Leponex
Last reviewed on 2024-06-28.
Cite this Page
Clozapine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000008704). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
DBLinks
- CAS Registry Number: 5786-21-0
- PubChem CID: 135398737
- ChEBI: 3766
- HMDB: HMDB0014507
- LipidMaps:
- KEGG: C06924
- BioCyc:
- NCBI MeSH: Clozapine
- Wikipedia: Clozapine
Other DBLinks
- CAS Registry Number: 1333667-72-3
- CAS Registry Number: 5786-21-0
- PubChem: 135398737
- PubChem: 2818
- ChEBI: ChEBI:3766
- HMDB: HMDB0014507
- KEGG: C06924
- NCBI MeSH: Clozapine
- Wikipedia: Clozapine
- DrugBank: DB00363
- RefMet: RM0136965
- MoNA: AU160001
- MoNA: AU160002
- MoNA: AU160003
- MoNA: AU160004
- MoNA: AU160005
- MoNA: AU160006
- MoNA: CCMSLIB00000078474
- MoNA: CCMSLIB00000078475
- MoNA: EA284101
- MoNA: EA284102
- MoNA: EA284103
- MoNA: EA284104
- MoNA: EA284105
- MoNA: EA284106
- MoNA: EA284107
- MoNA: EA284108
- MoNA: EA284109
- MoNA: EA284110
- MoNA: EA284111
- MoNA: EA284112
- MoNA: EA284113
- MoNA: EA284114
- MoNA: SM861001
- MoNA: WA001134
- MoNA: WA001135
- MoNA: WA001136
- MoNA: WA001137
- MoNA: WA001138
- MoNA: WA001139
- Metlin: METLIN_1901
- Coconut NaturalProduct: CNP0335979.0
Class / Ontology
- WishartLab ClassyFire: [Dibenzodiazepines] Dibenzodiazepines
- RefMet: [Dibenzodiazepines] Dibenzodiazepines
- ChEBI: [CHEBI:3766] clozapine
- Coconut NaturalProduct: [Anthranilic acid alkaloids] Anthranilic acid alkaloids
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| WikiPathways:WP2289 | Drug induction of bile acid pathway |
| WikiPathways:WP3253 | Drug induction of bile acid pathway |