Cimetidine (BioCAD00000008492)

blood urine

Metabolite Card

Formula: C10H16N6S (252.1157)
SMILES: C\N=C(\NCCSCC1=C(C)NC=N1)NC#N

Synonyms [en]

cimetidine; Cimetidina; 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine; Cimetag; Cimetidinum; N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Cimetidine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000008492). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]

Cytoplasm Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 270574-63-5
  • CAS Registry Number: 2984-61-4
  • CAS Registry Number: 51481-61-9
  • CAS Registry Number: 51481-61-9 (free)
  • CAS Registry Number: 76181-71-0
  • CAS Registry Number: 943920-67-0
  • PubChem: 2756
  • ChEBI: ChEBI:3699
  • HMDB: HMDB0014644
  • KEGG: C06952
  • NCBI MeSH: Cimetidine
  • Wikipedia: Cimetidine
  • DrugBank: DB00501
  • RefMet: RM0029834
  • MoNA: CCMSLIB00000077008
  • MoNA: EQ372201
  • MoNA: EQ372202
  • MoNA: EQ372203
  • MoNA: EQ372204
  • MoNA: EQ372205
  • MoNA: EQ372206
  • MoNA: EQ372207
  • MoNA: EQ372208
  • MoNA: EQ372209
  • MoNA: EQ372251
  • MoNA: EQ372252
  • MoNA: EQ372253
  • MoNA: EQ372254
  • MoNA: EQ372255
  • MoNA: EQ372256
  • MoNA: EQ372257
  • MoNA: EQ372258
  • MoNA: EQ372259
  • MoNA: KO000544
  • MoNA: KO000545
  • MoNA: KO000546
  • MoNA: KO000547
  • MoNA: KO000548
  • MoNA: KO002632
  • MoNA: KO002633
  • MoNA: KO002634
  • MoNA: KO002635
  • MoNA: KO002636
  • MoNA: KO008913
  • MoNA: KO008914
  • MoNA: KO008915
  • MoNA: KO008916
  • MoNA: KO008917
  • MoNA: MoNA033386
  • MoNA: MoNA033387
  • MoNA: MoNA033388
  • MoNA: MoNA033389
  • MoNA: MoNA033390
  • MoNA: MoNA033391
  • MoNA: MoNA035520
  • MoNA: MoNA035522
  • MoNA: MoNA035526
  • MoNA: MoNA036840
  • MoNA: MoNA036843
  • MoNA: MoNA036844
  • MoNA: MoNA036845
  • MoNA: MoNA036846
  • MoNA: MoNA036847
  • MoNA: MoNA037619
  • MoNA: MoNA037621
  • MoNA: MoNA038354
  • MoNA: MoNA038848
  • MoNA: MoNA038849
  • MoNA: WA001572
  • MoNA: WA001573
  • MoNA: WA001574
  • MoNA: WA001575
  • Metlin: METLIN_1755
  • Coconut NaturalProduct: CNP0480996.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP2289 Drug induction of bile acid pathway
WikiPathways:WP3253 Drug induction of bile acid pathway
PathBank:SMP0000617 Cimetidine Metabolism Pathway
PathBank:SMP0000232 Cimetidine Action Pathway
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