Cadaverine (BioCAD00000007798)

blood feces saliva urine epidermis intestine prostate plant natural products microbial natural products

Metabolite Card

Formula: C5H14N2 (102.1157)
SMILES: NCCCCCN

Synonyms [en]

cadaverine; pentamethylenediamine; 1,5-Diaminopentane; Pentane-1,5-diamine; 1,5-pentanediamine; Cadaverin

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Cadaverine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000007798). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. However, this diamine is not purely associated with putrefaction. Cadaverine is a toxic diamine with the formula NH2(CH2)5NH2, which is similar to putrescine's NH2(CH2)4NH2. Cadaverine is also known by the names 1,5-pentanediamine and pentamethylenediamine. It is also produced in small quantities by mammals. In particular, it is partially responsible for the distinctive smell of urine and semen. Elevated levels of cadaverine have been found in the urine of some patients with defects in lysine metabolism. Cadaverine is toxic in large doses. In rats it had a low acute oral toxicity of more than 2000 mg/kg body weight. Cadaverine can be found in Corynebacterium (PMID:27872963).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 462-94-2
  • PubChem: 273
  • PubChem: 4816
  • ChEBI: ChEBI:18127
  • HMDB: HMDB0002322
  • KEGG: C01672
  • BioCyc: CADAVERINE
  • NCBI MeSH: Cadaverine
  • Wikipedia: Cadaverine
  • DrugBank: DB03854
  • RefMet: RM0150157
  • MoNA: BAF_UVA_POS001569
  • MoNA: BAF_UVA_POS001570
  • MoNA: BAF_UVA_POS001571
  • MoNA: FiehnHILIC000235
  • MoNA: GLS00116
  • MoNA: HMDB0002322_c_ms_1519
  • MoNA: HMDB0002322_ms_ms_2055
  • MoNA: HMDB0002322_ms_ms_2056
  • MoNA: HMDB0002322_ms_ms_2057
  • MoNA: KO002542
  • MoNA: KO002543
  • MoNA: KO002544
  • MoNA: KO002545
  • MoNA: KO002546
  • MoNA: KZ000016
  • MoNA: KZ000112
  • MoNA: MoNA002142
  • MoNA: MoNA002143
  • MoNA: MoNA002144
  • MoNA: MoNA032300
  • MoNA: MoNA032301
  • MoNA: MoNA032302
  • MoNA: MoNA036205
  • MoNA: MoNA036206
  • MoNA: MoNA036207
  • MoNA: MoNA037240
  • MoNA: MoNA038617
  • MoNA: OUF00131
  • MoNA: PR010010
  • MoNA: PR100024
  • MoNA: PS004401
  • MoNA: PS004402
  • MoNA: PT100440
  • Metlin: METLIN_3236
  • Coconut NaturalProduct: CNP0184259.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00462 4.1.1.18 L-lysine carboxy-lyase (cadaverine-forming)
KEGG:R03666 C01672<=>C06181
KEGG:R06740 1.4.3.21 C01672 + C00001 + C00007<=>C12455 + C00014 + C00027
KEGG:R08359 2.5.1.16 S-adenosylmethioninamine:cadaverine 3-aminopropyltransferase
KEGG:R08418 C01672<=>C10773
KEGG:R08419 C01672<=>C10783
KEGG:R08421 C01672<=>C10772
KEGG:R09048 3 C01672 + 4 C00022<=>C18158 + 4 C00041 + 3 C00001
KEGG:R12214 2.6.1.82 cadaverine:2-oxoglutarate aminotransferase
KEGG:R12305 4.1.1.116 D-lysine carboxy-lyase
KEGG:R13598 1.14.13.- C01672 + C01352 + C00007<=>C23092 + C00016 + C00001
BioCyc:RXN0-5217 2.5.1.- CADAVERINE + S-ADENOSYLMETHIONINAMINE --> PROTON + CPD0-1065 + 5-METHYLTHIOADENOSINE
BioCyc:TRANS-RXN-68 lysine:cadaverine antiport
BioCyc:RXN0-7317 2.6.1.82 CADAVERINE + 2-KETOGLUTARATE<=>CPD-12763 + GLT
BioCyc:LYSDECARBOX-RXN 4.1.1.18 PROTON + LYS --> CARBON-DIOXIDE + CADAVERINE
BioCyc:TRANS-RXN0-212 cadaverine:proton symport
BioCyc:RXN-21437 4-AMINO-BUTYRALDEHYDE + CADAVERINE + NADH + PROTON --> CPD-23338 + WATER + NAD
BioCyc:RXN-8688 3 CADAVERINE + 4 PYRUVATE --> PROTON + CPD-8919 + 4 L-ALPHA-ALANINE + 3 WATER
BioCyc:RXN-21438 2.5.1.44 PUTRESCINE + CADAVERINE --> CPD-23338 + AMMONIUM
BioCyc:TRANS-RXN-426 cadaverine:proton antiport
View More
Organism Source

Taxonomy Source

  1. Arabidopsis thaliana [ncbi taxid: 3702]
  2. Capparis masaikai [ncbi taxid: 13395]
  3. Citrullus lanatus [ncbi taxid: 3654]
  4. Crenidium spinescens [ncbi taxid: 195729]
  5. Daphnia magna [ncbi taxid: 35525]
  6. Deinococcus radiodurans R1 ÃÂcrtLm/crtB+ dxs+ [crtLm crtB dxs] [ncbi taxid: ]
  7. Escherichia coli [ncbi taxid: 562]
  8. FOOD SAKE [ncbi taxid: ]
  9. Glycine max [ncbi taxid: 3847]
  10. Hemibarbus labeo [ncbi taxid: 328524]
  11. Hippobroma longiflora [ncbi taxid: 368676]
  12. Homo sapiens [ncbi taxid: 9606]
  13. Homo sapiens (Urine) [ncbi taxid: ]
  14. Huperzia serrata [ncbi taxid: 355589]
  15. Lathyrus sativus [ncbi taxid: 3860]
  16. Lobelia inflata [ncbi taxid: 308559]
  17. Lobelia siphilitica [ncbi taxid: 330173]
  18. Lupinus albus [ncbi taxid: 3870]
  19. Lupinus angustifolius [ncbi taxid: 3871]
  20. Lupinus arboreus [ncbi taxid: 3872]
  21. Lupinus hirsutus [ncbi taxid: ]
  22. Lupinus luteus [ncbi taxid: 3873]
  23. Lupinus mutabilis [ncbi taxid: 53232]
  24. Lupinus polyphyllus [ncbi taxid: 3874]
  25. Lupinus termis [ncbi taxid: ]
  26. Lyallia kerguelensis [ncbi taxid: 442941]
  27. Lycopodiastrum casuarinoides [ncbi taxid: 73626]
  28. Lycopodium annotinum [ncbi taxid: ]
  29. Mus musculus [ncbi taxid: 10090]
  30. Nectandra pichurim [ncbi taxid: ]
  31. Nicotiana acaulis [ncbi taxid: 118692]
  32. Nicotiana acuminata [ncbi taxid: 4086]
  33. Nicotiana africana [ncbi taxid: 200302]
  34. Nicotiana alata [ncbi taxid: 4087]
  35. Nicotiana ameghinoi [ncbi taxid: ]
  36. Nicotiana amplexicaulis [ncbi taxid: 118693]
  37. Nicotiana arentsii [ncbi taxid: 200319]
  38. Nicotiana attenuata [ncbi taxid: 49451]
  39. Nicotiana benavidesii [ncbi taxid: 118691]
  40. Nicotiana benthamiana [ncbi taxid: 4100]
  41. Nicotiana bigelovii [ncbi taxid: ]
  42. Nicotiana bonariensis [ncbi taxid: 118694]
  43. Nicotiana cavicola [ncbi taxid: 118690]
  44. Nicotiana clevelandii [ncbi taxid: 81866]
  45. Nicotiana cordifolia [ncbi taxid: 140890]
  46. Nicotiana corymbosa [ncbi taxid: 200301]
  47. Nicotiana debneyi [ncbi taxid: 4089]
  48. Nicotiana excelsior [ncbi taxid: 61185]
  49. Nicotiana exigua [ncbi taxid: 118695]
  50. Nicotiana forgetiana [ncbi taxid: 118696]
  51. Nicotiana fragrans [ncbi taxid: 118697]
  52. Nicotiana glauca [ncbi taxid: 4090]
  53. Nicotiana glutinosa [ncbi taxid: 35889]
  54. Nicotiana goodspeedii [ncbi taxid: 200305]
  55. Nicotiana gossei [ncbi taxid: 118698]
  56. Nicotiana hesperis [ncbi taxid: ]
  57. Nicotiana ingulba [ncbi taxid: ]
  58. Nicotiana kawakamii [ncbi taxid: 57321]
  59. Nicotiana knightiana [ncbi taxid: 118699]
  60. Nicotiana langsdorffii [ncbi taxid: 118700]
  61. Nicotiana linearis [ncbi taxid: 118701]
  62. Nicotiana longibracteata [ncbi taxid: ]
  63. Nicotiana longiflora [ncbi taxid: 118702]
  64. Nicotiana maritima [ncbi taxid: 200308]
  65. Nicotiana megalosiphon [ncbi taxid: 118703]
  66. Nicotiana miersii [ncbi taxid: 118704]
  67. Nicotiana nesophila [ncbi taxid: 200321]
  68. Nicotiana noctiflora [ncbi taxid: 118705]
  69. Nicotiana nudicaulis [ncbi taxid: 49452]
  70. Nicotiana occidentalis [ncbi taxid: 200313]
  71. Nicotiana otophora [ncbi taxid: 4091]
  72. Nicotiana paniculata [ncbi taxid: 62141]
  73. Nicotiana pauciflora [ncbi taxid: 200315]
  74. Nicotiana petunioides [ncbi taxid: 118708]
  75. Nicotiana plumbaginifolia [ncbi taxid: 4092]
  76. Nicotiana raimondii [ncbi taxid: 200312]
  77. Nicotiana repanda [ncbi taxid: 76336]
  78. Nicotiana rosulata [ncbi taxid: 200309]
  79. Nicotiana rotundifolia [ncbi taxid: 200310]
  80. Nicotiana rustica [ncbi taxid: 4093]
  81. Nicotiana setchellii [ncbi taxid: 200314]
  82. Nicotiana simulans [ncbi taxid: 118709]
  83. Nicotiana solanifolia [ncbi taxid: 118714]
  84. Nicotiana spegazzinii [ncbi taxid: 200300]
  85. Nicotiana stocktonii [ncbi taxid: 118710]
  86. Nicotiana suaveolens [ncbi taxid: 200320]
  87. Nicotiana sylvestris [ncbi taxid: 4096]
  88. Nicotiana tabacum [ncbi taxid: 4097]
  89. Nicotiana tabacum L. [ncbi taxid: ]
  90. Nicotiana thyrosiflora [ncbi taxid: ]
  91. Nicotiana tobacum [ncbi taxid: ]
  92. Nicotiana tomentosa [ncbi taxid: 57322]
  93. Nicotiana tomentosiformis [ncbi taxid: 4098]
  94. Nicotiana trigonophylla [ncbi taxid: 118711]
  95. Nicotiana undulata [ncbi taxid: 118713]
  96. Nicotiana velutina [ncbi taxid: 49454]
  97. Nicotiana wigandioides [ncbi taxid: 200317]
  98. Palhinhaea cernua [ncbi taxid: 73621]
  99. Piper longum [ncbi taxid: 49511]
  100. Piper nigrum [ncbi taxid: 13216]
  101. Piper trichostachyon [ncbi taxid: 1595995]
  102. Pisum sativum [ncbi taxid: ]
  103. Pityrogramma tartarea [ncbi taxid: ]
  104. Sedum acre [ncbi taxid: 23028]
  105. Sedum sarmentosum [ncbi taxid: 91146]
  106. Sophora subprostate [ncbi taxid: ]
  107. Sophorae flavescentis [ncbi taxid: ]
  108. Streptomyces lincolnensis ÃÂBGC33 [BGC33] [ncbi taxid: ]
  109. Streptomyces pilosus [ncbi taxid: 28893]
  110. Trifolium subterraneum [ncbi taxid: 3900]
  111. Uncaria rhynchophylla [ncbi taxid: 43575]
  112. Withania somnifera [ncbi taxid: 126910]

Pathway Synthetic

pathway id name
BioCyc:LEISH_POLYAMSYN-PWY superpathway of polyamine biosynthesis I
BioCyc:TRYPANO_ARG+POLYAMINE-SYN superpathway of arginine and polyamine biosynthesis
BioCyc:TRYPANO_PWY0-1303 aminopropylcadaverine biosynthesis
BioCyc:LEISH_PWY0-1303 aminopropylcadaverine biosynthesis
BioCyc:CAULONA1000_PWY0-461 lysine degradation I
BioCyc:TRYPANO_POLYAMSYN-PWY superpathway of polyamine biosynthesis I
PathBank:SMP0000795 Lysine Degradation I
PathBank:SMP0000808 Inner Membrane Transport
PathBank:SMP0002053 Aminopropylcadaverine Biosynthesis
Plant Reactome:R-FVE-1119446 Lysine degradation I
Plant Reactome:R-MES-2744345 Metabolism and regulation
Plant Reactome:R-MES-2744343 Amino acid metabolism
Plant Reactome:R-MES-5655124 Amino acid catabolism
Plant Reactome:R-TDI-2744345 Metabolism and regulation
Plant Reactome:R-TDI-2744343 Amino acid metabolism
Plant Reactome:R-TDI-1119446 Lysine degradation I
Plant Reactome:R-OGU-1119446 Lysine degradation I
Plant Reactome:R-PTI-2744345 Metabolism and regulation
Plant Reactome:R-PTI-2744343 Amino acid metabolism
Plant Reactome:R-PTI-5655124 Amino acid catabolism
View All Pathways