8(S)-HETE (BioCAD00000005589)

blood cerebrospinal fluid (csf)

Metabolite Card

Formula: C20H32O3 (320.2351)
SMILES: CCCCC\C=C/C\C=C/C=C/[C@@H](O)C\C=C/CCCC(O)=O

Synonyms [en]

8(S)-HETE; 8-HETE; 8S-HETE; (5Z,9E,11Z,14Z)-(8S)-8-Hydroxyeicosa-5,9,11,14-tetraenoic acid; 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid; (5Z,9E,11Z,14Z)-(8S)-8-Hydroxyicosa-5,9,11,14-tetraenoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

8(S)-HETE. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005589). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

8(S)-HETE is a naturally occurring hydroxyeicosatetraenoic acid eicosanoid. 8(S)-HETE is a strong activator of peroxisome proliferator-activated receptors (PPARs) alpha and a weak activator of PPAR gamma. PPARs are nuclear hormone receptors that regulate gene transcription in response to peroxisome proliferators and fatty acids. PPARs also play an important role in the regulation of adipocyte differentiation. It is unclear however what naturally occurring compounds activate each of the PPAR subtypes. Additionally, 8(S)-HETE is able to induce differentiation of preadipocytes. (PMID: 7592593, 9113987).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 98462-03-4
  • PubChem: 11976122
  • PubChem: 5283154
  • ChEBI: ChEBI:34486
  • ChEBI: ChEBI:72643
  • HMDB: HMDB0004679
  • HMDB: HMDB0062433
  • LipidMaps: LMFA03060006
  • LipidMaps: LMFA03060086
  • KEGG: C14776
  • Wikipedia: Vâlcele, Covasna
  • RefMet: RM0074129
  • RefMet: RM0153386
  • MoNA: IA000004
  • MoNA: IA000005
  • MoNA: IA000006
  • MoNA: IA000178
  • MoNA: IA000179
  • MoNA: IA000180
  • MoNA: IA000469
  • MoNA: IA000470
  • MoNA: IA000471
  • Metlin: METLIN_45730
  • Coconut NaturalProduct: CNP0177392.3
  • Coconut NaturalProduct: CNP0177392.4

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

pathway id name
WikiPathways:WP5155 Arachidonic acid (AA, ARA) oxylipin metabolism
WikiPathways:WP4348 Eicosanoid metabolism via lipoxygenases (LOX)
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
View All Pathways