Metabolite Card
Formula: C6H5NO3 (139.0269)
SMILES: OC(=O)C1=CN=C(O)C=C1
Synonyms [en]
6-hydroxynicotinic acid; 6-Hydroxynicotinate; 6-hydroxypyridine-3-carboxylic acid; 5-Carboxy-2-pyridone; 2-Hydroxy-5-carboxypyridine; 2-Pyridone-5-carboxylic acid
Last reviewed on 2024-06-28.
Cite this Page
6-Hydroxynicotinate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000005210). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
6-Hydroxynicotinic acid (6-OHNA) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. Among the common bacteria causing urinary infection, only P. aeruginosa produces 6-hydroxynicotinic acid from nicotinic acid. Pseudomonas aeruginosa infection has been reported to be the third leading cause of urinary infection, accounting for 11% of such infections, the first and second being Escherichia coli and Klebsiella pneumonia, respectively. Analyses of the NMR spectra of the bacterial media with variable cell count of P. aeruginosa, shows that the intensity of the signals of the 6-hydroxynicotinic acid increases with increasing number of bacterial cells (PMID:3926801, 15759292). 6-hydroxynicotinic acid can also be found in Achromobacter and Serratia.
DBLinks
- CAS Registry Number: 5006-66-6
- PubChem CID: 72924
- ChEBI: 16168
- HMDB: HMDB0002658
- LipidMaps:
- KEGG: C01020
- BioCyc:
- NCBI MeSH: 6-hydroxynicotinic acid
- Wikipedia:
Other DBLinks
- CAS Registry Number: 15864-85-4
- CAS Registry Number: 5006-66-6
- PubChem: 4265
- PubChem: 72924
- ChEBI: ChEBI:16168
- HMDB: HMDB0002658
- HMDB: HMDB02658
- KEGG: C01020
- NCBI MeSH: 6-hydroxynicotinic acid
- RefMet: RM0156701
- MoNA: BAF_UVA_POS000978
- MoNA: BAF_UVA_POS000979
- MoNA: BAF_UVA_POS001371
- MoNA: CCMSLIB00000578018
- MoNA: CCMSLIB00000578262
- MoNA: CCMSLIB00005463984
- MoNA: CCMSLIB00005463989
- MoNA: EMBL-MCF_spec58033
- MoNA: FiehnHILIC001029
- MoNA: FiehnLib000550
- MoNA: GLS00048
- MoNA: HMDB0002658_c_ms_1266
- MoNA: KO000988
- MoNA: KO000989
- MoNA: KO000990
- MoNA: KO000991
- MoNA: KO000992
- MoNA: KO003078
- MoNA: KO003079
- MoNA: KO003080
- MoNA: KO003081
- MoNA: KO003082
- MoNA: MoNA002034
- MoNA: MoNA002035
- MoNA: MoNA002037
- MoNA: MoNA016646
- MoNA: MoNA023955
- MoNA: MoNA023967
- MoNA: MoNA032204
- MoNA: MoNA032205
- MoNA: MoNA032206
- MoNA: MoNA034160
- MoNA: MoNA034164
- MoNA: MoNA034166
- MoNA: MoNA037201
- MoNA: MoNA037914
- MoNA: OUF00085
- MoNA: PR100297
- MoNA: PR100298
- MoNA: PR100730
- MoNA: PS063901
- MoNA: PS063902
- MoNA: PS063903
- MoNA: PS063907
- MoNA: PT106390
- MoNA: PT106393
- MoNA: PT206390
- Metlin: METLIN_3264
- Coconut NaturalProduct: CNP0253562.0
- Coconut NaturalProduct: CNP0320055.0
- Coconut NaturalProduct: CNP0533542.0
Class / Ontology
- WishartLab ClassyFire: [Pyridinecarboxylic acids and derivatives] Pyridinecarboxylic acids and derivatives
- RefMet: [Nicotinic acid alkaloids] Nicotinic acid alkaloids
- ChEBI: [CHEBI:16168] 6-hydroxynicotinic acid
- Coconut NaturalProduct: [Pyridine alkaloids] Pyridine alkaloids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00047 | 1.14.99.- | 6-hydroxynicotinate,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating, decarboxylating) |
| KEGG:R01720 | 1.17.1.5 | nicotinate:NADP+ 6-oxidoreductase (hydroxylating) |
| KEGG:R03164 | 1.3.7.1 | 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase |
| KEGG:R07221 | 1.17.3.3 | 6-hydroxynicotinate:O2 oxidoreductase |
| KEGG:R08764 | 1.14.13.114 | 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating) |
| KEGG:R09473 | 1.17.2.1 | nicotinate:cytochrome 6-oxidoreductase (hydroxylating) |
Taxonomy Source
- Arabidopsis thaliana [ncbi taxid: 3702]
- Homo sapiens [ncbi taxid: 9606]
- Mus musculus [ncbi taxid: 10090]
Pathway Synthetic
| pathway id | name |
|---|