5'-Phosphoribosylglycinamide (BioCAD00000005034)

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Metabolite Card

Formula: C7H15N2O8P (286.0566)
SMILES: NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

Synonyms [en]

5'-phosphoribosylglycinamide; Glycinamide ribonucleotide; N1-(5-Phospho-D-ribosyl)glycinamide; GAR; glycineamideribotide; N(1)-(5-phospho-D-Ribosyl)glycinamide

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

5'-Phosphoribosylglycinamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005034). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Glycinamidoribotide conversion to N-formylglycinamide ribonucleotide is the third reaction of the de novo purine biosynthesis, a reaction catalyzed by the enzyme Glycinamide ribonucleotide transformylase (EC 2.1.2.2), with concomitant conversion of 10-formyltetrahydrofolate to tetrahydrofolate. (PMID: 9143358). Glycineamideribotide formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49). (PMID: 4366083).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 10074-18-7
  • CAS Registry Number: 147651-18-1
  • PubChem: 160913
  • PubChem: 5459918
  • ChEBI: ChEBI:18349
  • HMDB: HMDB0002022
  • KEGG: C03838
  • NCBI MeSH: glycinamide ribonucleotide
  • NCBI MeSH: glycineamide ribonucleotide
  • Wikipedia: Glycineamide ribonucleotide
  • Wikipedia: Glycineamide_ribonucleotide
  • DrugBank: DB02236
  • RefMet: RM0136854
  • Metlin: METLIN_3411
  • Coconut NaturalProduct: CNP0297680.1
  • Coconut NaturalProduct: CNP0297680.3

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R04144 6.3.4.13 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
KEGG:R04325 2.1.2.2 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase
KEGG:R04326 2.1.2.2 C03838 + C00445 + C00001<=>C04376 + C00101
KEGG:R06974 6.3.1.21 formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
BioCyc:TRYPANO_PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis
BioCyc:TRYPANO_DENOVOPURINE2-PWY purine nucleotides de novo biosynthesis I
BioCyc:TRYPANO_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:TRYPANO_PWY-841 purine nucleotides de novo biosynthesis II
BioCyc:TRYPANO_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
PathBank:SMP0001750 One Carbon Pool by Folate
WikiPathways:WP2185 Purine metabolism
WikiPathways:WP1075 Folate metabolism
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP176 Folate metabolism
PathBank:SMP0120670 Adenylosuccinate Lyase Deficiency
PathBank:SMP0120448 Adenosine Deaminase Deficiency
PathBank:SMP0120452 AICA-Ribosiduria
PathBank:SMP0120508 Lesch-Nyhan Syndrome (LNS)
PathBank:SMP0120532 Molybdenum Cofactor Deficiency
PathBank:SMP0120536 Purine Nucleoside Phosphorylase Deficiency
PathBank:SMP0120577 Xanthinuria Type I
PathBank:SMP0120601 Mitochondrial DNA Depletion Syndrome
PathBank:SMP0122040 One Carbon Pool by Folate
PathBank:SMP0000167 Adenylosuccinate Lyase Deficiency
View All Pathways