Metabolite Card
Formula: C17H30Cl2N5O8PS (565.093)
SMILES: NC(CCC(O)=NC(CSC1CCOP(=O)(N1)N(CCCl)CCCl)C(O)=NCC(O)=O)C(O)=O
Synonyms [en]
4-Glutathionyl cyclophosphamide; 2-amino-4-{[2-({2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ⁵-oxazaphosphinan-4-yl}sulfanyl)-1-[(carboxymethyl)-C-hydroxycarbonimidoyl]ethyl]-C-hydroxycarbonimidoyl}butanoic acid
Last reviewed on 2024-06-28.
Cite this Page
4-Glutathionyl cyclophosphamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000004307). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
4-Glutathionyl cyclophosphamide is a metabolite of cyclophosphamide. Cyclophosphamide ( trade names Endoxan, Cytoxan, Neosar, Procytox, Revimmune), also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. It is used to treat various types of cancer and some autoimmune disorders. (Wikipedia)
DBLinks
- CAS Registry Number:
- PubChem CID: 443288
- ChEBI: 1831
- HMDB: HMDB0060387
- LipidMaps:
- KEGG: C11583
- BioCyc:
- NCBI MeSH:
- Wikipedia:
Other DBLinks
- PubChem: 443288
- ChEBI: ChEBI:1831
- HMDB: HMDB0060387
- KEGG: C11583
- Metlin: METLIN_69111
Class / Ontology
- WishartLab ClassyFire: [Amino acids, peptides, and analogues] Amino acids, peptides, and analogues
- ChEBI: [CHEBI:1831] 4-Glutathionyl cyclophosphamide
| ID | EC Number | Name |
|---|---|---|
| KEGG:R08280 | 2.5.1.18 | 4-glutathionyl cyclophosphamide hydrolase |
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000447 | Cyclophosphamide Action Pathway |
| PathBank:SMP0000604 | Cyclophosphamide Metabolism Pathway |