3-Hydroxyisovaleryl-CoA (BioCAD00000003577)

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Metabolite Card

Formula: C26H44N7O18P3S (867.1676)
SMILES: CC(C)(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N

Synonyms [en]

3-Hydroxyisovaleryl-CoA; 3-Hydroxyisovaleryl coenzyme A; 3-hydroxy-3-methylbutyryl-CoA; 3-hydroxy-3-methylbutyryl-coenzyme A; 3-Hydroxy-3-methylbutanoyl-CoA; beta-hydroxyisovaleryl-coenzyme-A

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

3-Hydroxyisovaleryl-CoA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000003577). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

3-Hydroxyisovaleryl-CoA is an end product of leucine degradation. It is converted from 3-methylbut-2-enoyl-CoA by the enzyme enoyl-CoA hydratase.

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • PubChem: 11953876
  • PubChem: 11966188
  • ChEBI: ChEBI:28291
  • HMDB: HMDB0006870
  • HMDB: HMDB06870
  • LipidMaps: LMFA07050222
  • KEGG: C05998
  • BioCyc: 3-HYDROXY-ISOVALERYL-COA
  • RefMet: RM0153992
  • Metlin: METLIN_58575
  • Coconut NaturalProduct: CNP0083528.1
  • Coconut NaturalProduct: CNP0083528.2

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R04137 4.2.1.17 3-hydroxyisovaleryl-CoA hydro-lyase
KEGG:R10759 C05998<=>C20827
BioCyc:RXN-14266 4.2.1.17 3-hydroxyisovaleryl-CoA hydratase
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP662 Amino acid metabolism
WikiPathways:WP1451 Valine, leucine and isoleucine degradation
WikiPathways:WP3925 Amino acid metabolism
PathBank:SMP0120662 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120806 3-Hydroxyisobutyric Aciduria
PathBank:SMP0120440 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120444 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120516 Maple Syrup Urine Disease
PathBank:SMP0120589 Isovaleric Acidemia
PathBank:SMP0000032 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0000173 beta-Ketothiolase Deficiency
PathBank:SMP0000199 Maple Syrup Urine Disease
PathBank:SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000141 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0000524 Isovaleric Acidemia
PathBank:SMP0087234 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120661 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120665 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120745 Methylmalonic Aciduria
View All Pathways