(2E)-2-Heptenal (BioCAD00000030781)

blood saliva plant natural products microbial natural products

Metabolite Card

Formula: C7H12O (112.0888)
SMILES: CCCC\C=C\C=O

Synonyms [en]

2-heptenal; Butylacrolein; (2E)-2-Heptenal; trans-2-Heptenal; Hept-(E)-2-enal; Hept-2(E)-enal

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

(2E)-2-Heptenal. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000030781). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

(2E)-2-Heptenal, also known as 3-butylacrolein or 2-trans-heptenal, belongs to the class of organic compounds known as medium-chain aldehydes. These are an aldehyde with a chain length containing between 6 and 12 carbon atoms. (2E)-2-Heptenal is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Thus, (2E)-2-heptenal is considered to be a fatty aldehyde lipid molecule. Uremic toxins such as 2-Heptenal are actively transported into the kidneys via organic ion transporters (especially OAT3). (2E)-2-Heptenal is an almond, and fatty tasting compound. (2E)-2-Heptenal is found, on average, in the highest concentration within safflowers. (2E)-2-Heptenal has also been detected, but not quantified, in several different foods, such as roselles, common grapes, cucumbers, garden tomato, and evergreen blackberries. (2E)-2-Heptenal is a potentially toxic compound. Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. As a uremic toxin, this compound can cause uremic syndrome. Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma.

Cytoplasm Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 1070-66-2
  • CAS Registry Number: 18829-55-5
  • CAS Registry Number: 2463-63-0
  • CAS Registry Number: 29381-66-6
  • PubChem: 17167
  • PubChem: 5283316
  • ChEBI: ChEBI:143912
  • ChEBI: ChEBI:61724
  • HMDB: HMDB0033827
  • LipidMaps: LMFA06000019
  • NCBI MeSH: 2-heptenal
  • RefMet: RM0140015
  • MoNA: HMDB0033827_c_ms_101410
  • MoNA: JP008678
  • Metlin: METLIN_75301
  • Coconut NaturalProduct: CNP0210810.0
  • Coconut NaturalProduct: CNP0555185.0

Class / Ontology

Metabolic Network
ID EC Number Name
Rhea:RHEA:60721 (E)-hept-2-enal + NADP+ + H2O => (E)-hept-2-enoate + NADPH + 2 H+
Rhea:RHEA:60722 (E)-hept-2-enoate + NADPH + 2 H+ => (E)-hept-2-enal + NADP+ + H2O
Rhea:RHEA:60723 (E)-hept-2-enal + NADP+ + H2O <=> (E)-hept-2-enoate + NADPH + 2 H+
Rhea:RHEA:67261 (E)-hept-2-enal + NAD+ + H2O => (E)-hept-2-enoate + NADH + 2 H+
Rhea:RHEA:67262 (E)-hept-2-enoate + NADH + 2 H+ => (E)-hept-2-enal + NAD+ + H2O
Rhea:RHEA:67263 (E)-hept-2-enal + NAD+ + H2O <=> (E)-hept-2-enoate + NADH + 2 H+
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Organism Source

Taxonomy Source

  1. Acacia mearnsii [ncbi taxid: 139012]
  2. Akebia quinata [ncbi taxid: 13331]
  3. Akebia trifoliata [ncbi taxid: 155132]
  4. Alangium premnifolium [ncbi taxid: 2918396]
  5. Aloe africana [ncbi taxid: 1080010]
  6. Aloe ferox [ncbi taxid: 117798]
  7. Aloe spicata [ncbi taxid: 992642]
  8. Aloe vera [ncbi taxid: 34199]
  9. Angelica tarokoensis [ncbi taxid: 2831630]
  10. Artemisia argyi [ncbi taxid: 259893]
  11. Artemisia montana [ncbi taxid: 669134]
  12. Artemisia princeps [ncbi taxid: 223870]
  13. Atractylodes lancea [ncbi taxid: 41486]
  14. Atractylodes macrocephala [ncbi taxid: 265785]
  15. Bombax ceiba [ncbi taxid: 45325]
  16. Bragantia wallichii [ncbi taxid: ]
  17. Bupleurum chinense [ncbi taxid: 52451]
  18. Bupleurum falcatum [ncbi taxid: 46367]
  19. Bupleurum scorzonerifolium [ncbi taxid: 48105]
  20. Camellia saluenensis [ncbi taxid: 319929]
  21. Camellia sinensis [ncbi taxid: 4442]
  22. Carthamus tinctorius [ncbi taxid: 4222]
  23. Citrullus lanatus [ncbi taxid: 3654]
  24. Citrullus lanatus subsp. vulgaris [ncbi taxid: ]
  25. Clausena excavata [ncbi taxid: 76959]
  26. Colobocentrotus atratus [ncbi taxid: 39290]
  27. Delphinium andersoni [ncbi taxid: ]
  28. Dendrobium chrysanthum [ncbi taxid: 154291]
  29. Dendrobium fimbriatum var. oculatum [ncbi taxid: 2821054]
  30. Diphasia angolensis [ncbi taxid: ]
  31. Epimedium davidii [ncbi taxid: 253605]
  32. Erysimum odoratum [ncbi taxid: 1137569]
  33. Eupolyphaga sinensis [ncbi taxid: 367774]
  34. Eutypella scoparia [ncbi taxid: ]
  35. Exodermis poria [ncbi taxid: ]
  36. Frullania tamarisci [ncbi taxid: 95764]
  37. Galenia africana [ncbi taxid: ]
  38. Gardenia jasminoides [ncbi taxid: 114476]
  39. Globba malaccensis [ncbi taxid: ]
  40. Gnidia lamprantha [ncbi taxid: ]
  41. Hansenia forbesii [ncbi taxid: 165499]
  42. Hansenia weberbaueriana [ncbi taxid: 54724]
  43. Hericium erinaceus [ncbi taxid: 91752]
  44. Heterotheca inuloides [ncbi taxid: 3015714]
  45. Homo sapiens [ncbi taxid: 9606]
  46. Ilex amara [ncbi taxid: 185490]
  47. Isodon japonicus [ncbi taxid: 425908]
  48. Knightia excelsa [ncbi taxid: 35944]
  49. Kobus ellipsiprymnus [ncbi taxid: 9962]
  50. Laurencia distichophylla [ncbi taxid: ]
  51. Leonurus glaucescens [ncbi taxid: 445399]
  52. Lepidium draba [ncbi taxid: 153317]
  53. Lycium barbarum [ncbi taxid: 112863]
  54. Lycium chinense [ncbi taxid: 112883]
  55. Maba buxifolia [ncbi taxid: ]
  56. Micromeria pineolens [ncbi taxid: 306397]
  57. Nemalion vermiculare [ncbi taxid: 935621]
  58. Nidula candida [ncbi taxid: 1348642]
  59. Ophiocoma scolopendrina [ncbi taxid: 1365868]
  60. Ostericum grosseserratum [ncbi taxid: 182415]
  61. Panax ginseng [ncbi taxid: 4054]
  62. Panax notoginseng [ncbi taxid: 44586]
  63. Panax quinquefolius [ncbi taxid: 44588]
  64. Patrinia scabiosifolia [ncbi taxid: 300888]
  65. Patrinia villosa [ncbi taxid: 183944]
  66. Penicillium citreonigrum [ncbi taxid: 69768]
  67. Prunus armeniaca [ncbi taxid: 36596]
  68. Prunus armeniaca L. (K113-40,K33-81) [ncbi taxid: ]
  69. Quercus sessiliflora [ncbi taxid: ]
  70. Salacia madagascariensis [ncbi taxid: 670374]
  71. Saussurea carthamoides [ncbi taxid: ]
  72. Semen sesami [ncbi taxid: ]
  73. Solanum acaule [ncbi taxid: 103871]
  74. Spodoptera eridania [ncbi taxid: 37547]
  75. Spongiporus leucomallellus (Murril) [ncbi taxid: ]
  76. Sraitia grosvenorii [ncbi taxid: ]
  77. Streptomyces griseovariabilis [ncbi taxid: 284636]
  78. Swertia delavayi [ncbi taxid: 166617]
  79. Vaccinium vitis-idaea [ncbi taxid: 180772]
  80. Vallota purpurea [ncbi taxid: ]
  81. Vismia jefensis [ncbi taxid: ]
  82. Zea mays [ncbi taxid: 4577]

Pathway Synthetic

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