4',5,7-Trimethoxyflavone (BioCAD00000028275)

plant natural products microbial natural products

Metabolite Card

Formula: C18H16O5 (312.0998)
SMILES: COC1=CC=C(C=C1)C1=CC(=O)C2=C(OC)C=C(OC)C=C2O1

Synonyms [en]

4',5,7-trimethoxyflavone; Apigenin 5,7,4'-trimethyl ether; Trimethylapigenin; Apigenin trimethyl ether; 5,7,4'-Trimethoxyflavone; 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

4',5,7-Trimethoxyflavone. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000028275). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

4',5,7-Trimethoxyflavone, also known as trimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4',5,7-trimethoxyflavone is considered to be a flavonoid lipid molecule. 4',5,7-Trimethoxyflavone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, 4',5,7-trimethoxyflavone has been detected, but not quantified in, a few different foods, such as citrus, mandarin orange (clementine, tangerine), and sweet oranges. This could make 4',5,7-trimethoxyflavone a potential biomarker for the consumption of these foods.

Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 127073-90-9
  • CAS Registry Number: 5631-70-9
  • CAS Registry Number: 720675-70-7
  • CAS Registry Number: 80710-39-0
  • PubChem: 79730
  • ChEBI: ChEBI:174981
  • HMDB: HMDB0030842
  • LipidMaps: LMPK12111071
  • KEGG: C14985
  • NCBI MeSH: 5,7,4'-trimethylapigenin
  • Metlin: METLIN_43862
  • Metlin: METLIN_82418
  • Coconut NaturalProduct: CNP0063760.0
  • Coconut NaturalProduct: CNP0068574.0
  • Coconut NaturalProduct: CNP0076775.0
  • Coconut NaturalProduct: CNP0103321.0
  • Coconut NaturalProduct: CNP0161436.0
  • Coconut NaturalProduct: CNP0161928.0
  • Coconut NaturalProduct: CNP0171103.0
  • Coconut NaturalProduct: CNP0231902.0
  • Coconut NaturalProduct: CNP0268298.0
  • Coconut NaturalProduct: CNP0331150.0
  • Coconut NaturalProduct: CNP0345792.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Aquilaria sinensis [ncbi taxid: 210372]
  2. Aceriphyllum rossii [ncbi taxid: ]
  3. Aconitum variegatum [ncbi taxid: 112594]
  4. Agnorhiza bolanderi [ncbi taxid: 230216]
  5. Alligator mississippiensis [ncbi taxid: 8496]
  6. Amorphophallus konjac [ncbi taxid: 78372]
  7. Anaxagorea clavata [ncbi taxid: ]
  8. Aniba santalodora [ncbi taxid: ]
  9. Araujia sericifera [ncbi taxid: 63463]
  10. Aria pallescens [ncbi taxid: ]
  11. Arnica nevadensis [ncbi taxid: 436208]
  12. Artemisia monogyna [ncbi taxid: 1903222]
  13. Astragalus circassicus [ncbi taxid: ]
  14. Axinyssa variabilis [ncbi taxid: 2606642]
  15. Bassia butyracea [ncbi taxid: ]
  16. Beilschmiedia madang [ncbi taxid: ]
  17. Bethencourtia palmensis [ncbi taxid: 462391]
  18. Beyeria brevifolia [ncbi taxid: 2752376]
  19. Boesenbergia pandurata [ncbi taxid: ]
  20. Boswellia ovalifoliolata [ncbi taxid: 613108]
  21. Bursaria spinosa [ncbi taxid: 105281]
  22. Calophyllum inophyllum [ncbi taxid: 158927]
  23. Campanula choziatowskyi [ncbi taxid: ]
  24. Centaurea scoparia [ncbi taxid: 2072395]
  25. Centaurea sonchifolia [ncbi taxid: ]
  26. Cheilanthes fragrans [ncbi taxid: ]
  27. Chloranthus tianmushanensis [ncbi taxid: ]
  28. Chlorociboria aeruginascens [ncbi taxid: 296797]
  29. Chromolaena odorata [ncbi taxid: 103745]
  30. Chromolaena pulchella [ncbi taxid: ]
  31. Citrus aurantium [ncbi taxid: ]
  32. Citrus grandis [ncbi taxid: ]
  33. Citrus grandis var.tomentosa [ncbi taxid: ]
  34. Citrus reticulata [ncbi taxid: 85571]
  35. Citrus reticulate [ncbi taxid: ]
  36. Citrus sinensis [ncbi taxid: 2711]
  37. Cladonia evansii [ncbi taxid: 197026]
  38. Clonostachys rosea [ncbi taxid: 29856]
  39. Coccus fagi [ncbi taxid: ]
  40. Colchicum filifolium [ncbi taxid: 280460]
  41. Cynoglossum macrostylum [ncbi taxid: 1452877]
  42. Daphne genkwa [ncbi taxid: 1477590]
  43. Dendrosenecio kilimanjari [ncbi taxid: 109559]
  44. Dialium excelsum [ncbi taxid: 1608024]
  45. Dipterocarpus alatus [ncbi taxid: 340438]
  46. Drosera peltata [ncbi taxid: 4369]
  47. Drymaria cordata [ncbi taxid: 191453]
  48. Dysidea fragilis [ncbi taxid: 1336851]
  49. Echinops amplexicaulis [ncbi taxid: 910522]
  50. Epaltes gariepina [ncbi taxid: 1548596]
  51. Erythrina hypaphorus [ncbi taxid: ]
  52. Esox lucius [ncbi taxid: 8010]
  53. Etmopterus spinax [ncbi taxid: 648166]
  54. Euphorbia hylonoma [ncbi taxid: 526195]
  55. Fadogia agrestis [ncbi taxid: ]
  56. Ficus formosana [ncbi taxid: 1127366]
  57. Fusarium gibbosum [ncbi taxid: 2126134]
  58. Garcinia kola [ncbi taxid: 469930]
  59. Gardenia fosbergii [ncbi taxid: ]
  60. Hardenbergia violacea [ncbi taxid: 53885]
  61. Heliotropium scabrum [ncbi taxid: ]
  62. Helleborus macranthus [ncbi taxid: ]
  63. Hypericum reflexum [ncbi taxid: 673932]
  64. Ilex affinis [ncbi taxid: 185489]
  65. Iris kashmiriana [ncbi taxid: ]
  66. Isodon kameba [ncbi taxid: ]
  67. Kaempferia parviflora [ncbi taxid: 97751]
  68. Kaempferia pulchra [ncbi taxid: 199647]
  69. Lactarius mitissimus [ncbi taxid: 118866]
  70. Lactarius scrobiculatus [ncbi taxid: 93011]
  71. Lactarius spinosulus [ncbi taxid: 152946]
  72. Lemonia spectabilis [ncbi taxid: ]
  73. Lepechinia urbanii [ncbi taxid: 1405049]
  74. Lonchocarpus chiricanus [ncbi taxid: 1582177]
  75. Maclura cochinchinensis [ncbi taxid: 194324]
  76. Markhamia stipulata [ncbi taxid: 1489749]
  77. Matricaria sabulosa [ncbi taxid: ]
  78. Matsucoccus josephi [ncbi taxid: ]
  79. Mentzelia decapetala [ncbi taxid: 37834]
  80. Mimosa pigra [ncbi taxid: 367322]
  81. Mollugo spergula [ncbi taxid: ]
  82. Mucuna holtonii [ncbi taxid: 1127093]
  83. Myrsine capitellata [ncbi taxid: ]
  84. Nepytia freemani [ncbi taxid: 942327]
  85. Nicotiana affinis [ncbi taxid: ]
  86. Odixia angusta [ncbi taxid: 125740]
  87. Orgyia pseudotsugata [ncbi taxid: 33414]
  88. Orthosiphon spicatus [ncbi taxid: ]
  89. Osteospermum fruticosum [ncbi taxid: ]
  90. Ostrya carpinifolia [ncbi taxid: 176865]
  91. Parmotrema nilgherrense [ncbi taxid: 1450753]
  92. Petunia axillaris subsp. parodii [ncbi taxid: 55890]
  93. Pheidole pallidula [ncbi taxid: 190770]
  94. Phomopsis leptostromiformis [ncbi taxid: ]
  95. Podocarpus dacrydioides [ncbi taxid: ]
  96. Preussia terricola [ncbi taxid: 265085]
  97. Prosopis glandulosa [ncbi taxid: ]
  98. Prunus laurocerasus [ncbi taxid: 32242]
  99. Pseudopterogorgia kallos [ncbi taxid: ]
  100. Pteris prolifera [ncbi taxid: ]
  101. Pterocarpus grandiflorus [ncbi taxid: ]
  102. Pterocaulon serrulatum [ncbi taxid: 1548653]
  103. Pulsatilla chinensis [ncbi taxid: 714493]
  104. Pyrosoma giganteum [ncbi taxid: ]
  105. Quercus aegilops [ncbi taxid: ]
  106. Quercus marilandica [ncbi taxid: 478951]
  107. Rhizobium phaseoli [ncbi taxid: 396]
  108. Rubia akane [ncbi taxid: ]
  109. Salix rosmarinifolia [ncbi taxid: 2720589]
  110. Salvia lavanduloides [ncbi taxid: 392669]
  111. Salvia officinalis [ncbi taxid: 38868]
  112. Salvia patens [ncbi taxid: 392677]
  113. Salvia virgata [ncbi taxid: 1298553]
  114. Securidaca inappendiculata [ncbi taxid: 3091905]
  115. Senecio platyphylloides [ncbi taxid: ]
  116. Senecio sandersonii [ncbi taxid: 1892294]
  117. Senecio squalidus [ncbi taxid: 121554]
  118. Seriphidium cinum [ncbi taxid: ]
  119. Sesbania punicea [ncbi taxid: 543741]
  120. Sideritis soluta [ncbi taxid: 155263]
  121. Sideritis trojana [ncbi taxid: 703113]
  122. Simira eliezeriana [ncbi taxid: ]
  123. Sphaeria rousseliana [ncbi taxid: ]
  124. Stenostomum lucidum [ncbi taxid: 43446]
  125. Stephania dielsiana [ncbi taxid: 1501458]
  126. Streptomyces althioticus [ncbi taxid: 83380]
  127. Streptomyces avermitilis (SaOMT2) [ncbi taxid: ]
  128. Taxodium mucronatum [ncbi taxid: 99812]
  129. Thalassiosira weissflogii [ncbi taxid: ]
  130. Viguiera stenoloba [ncbi taxid: ]
  131. Vinca minor [ncbi taxid: 60093]
  132. Vitex madiensis [ncbi taxid: 1899206]
  133. Eschscholzia californica [ncbi taxid: 3467]
  134. Iryanthera juruensis [ncbi taxid: 3126644]
  135. Myroxylon peruiferum [ncbi taxid: 1231556]
  136. Umtiza listerana [ncbi taxid: ]

Pathway Synthetic

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