2-Phospho-D-glycerate (BioCAD00000002792)

urine placenta

Metabolite Card

Formula: C3H7O7P (185.9929)
SMILES: OC[C@@H](OP(O)(O)=O)C(O)=O

Synonyms [en]

D-Glycerate 2-phosphate; 2-phospho-D-glycerate; 2-Phospho-D-Glyceric Acid; (2R)-3-hydroxy-2-(phosphonooxy)propanoic acid; 2-Phospho-(R)-glycerate; D-Glyceric acid 2-phosphate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

2-Phospho-D-glycerate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000002792). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

2-Phospho-D-glycerate or 2PG is an intermediate in gluconeogenesis. It is a glyceric acid which serves as the substrate in the ninth step of glycolysis. 2PG is converted by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. More specifically, 2PG can be generated from Glycerate-3-phosphate via phosphoglycerate mutase or from phosphoenolpyrvate via alpha enolase.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 3443-57-0
  • CAS Registry Number: 3443-58-1
  • PubChem: 439278
  • ChEBI: ChEBI:17835
  • ChEBI: ChEBI:24344
  • HMDB: HMDB0003391
  • KEGG: C00631
  • BioCyc: 2-PG
  • DrugBank: DB01709
  • DrugBank: DB03465
  • RefMet: RM0136217
  • MoNA: HMDB0003391_c_ms_1458
  • MoNA: KO001595
  • MoNA: KO001596
  • MoNA: KO001597
  • MoNA: KO001598
  • MoNA: KO001599
  • MoNA: KO003690
  • MoNA: KO003691
  • MoNA: KO003692
  • MoNA: KO003693
  • MoNA: KO003694
  • Metlin: METLIN_151
  • Coconut NaturalProduct: CNP0165891.0
  • Coconut NaturalProduct: CNP0190729.1
  • Coconut NaturalProduct: CNP0586930.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00658 4.2.1.11 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
KEGG:R01518 5.4.2.11 D-phosphoglycerate 2,3-phosphomutase
KEGG:R01748 3.1.3.20 D-glycerate-2-phosphate phosphohydrolase
KEGG:R02664 2.7.2.16 C00631 + C00002<=>C01159 + C00008
KEGG:R08572 2.7.1.165 ATP:(R)-glycerate 2-phosphotransferase
KEGG:R09532 3.1.3.80 2,3-bisphospho-D-glycerate 3-phosphohydrolase
BioCyc:3PGAREARR-RXN 5.4.2.12 2-PG<=>G3P
BioCyc:2PGADEHYDRAT-RXN 4.2.1.11 2-PG<=>PHOSPHO-ENOL-PYRUVATE + WATER
BioCyc:GKI-RXN 2.7.1.165 GLYCERATE + ATP<=>PROTON + 2-PG + ADP
BioCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN 3.1.3.20 WATER + 2-PG --> GLYCERATE + Pi
BioCyc:RXN-15513 5.4.2.11 2-PG<=>G3P
BioCyc:RXN-15510 Protein-pi-phospho-L-histidines + 2-PG<=>Protein-Histidines + 23-DIPHOSPHOGLYCERATE
BioCyc:RXN-20987 2.7.2.16 ATP + 2-PG --> ADP + 23-DIPHOSPHOGLYCERATE + PROTON
BioCyc:RXN-11102 3.1.3.80 23-DIPHOSPHOGLYCERATE + WATER --> 2-PG + Pi
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Organism Source

Taxonomy Source

  1. Escherichia coli [ncbi taxid: 562]
  2. Mus musculus [ncbi taxid: 10090]
  3. Oryza sativa [ncbi taxid: 4530]
  4. Capsicum annuum [ncbi taxid: 4072]

Pathway Synthetic

pathway id name
BioCyc:LEISH_PWY3IU-99 superpathway of central carbon metabolism
BioCyc:LEISH_GLYCOLYSIS glycolysis I
BioCyc:LEISH_GLUCONEO-PWY gluconeogenesis I
BioCyc:TRYPANO_PWY-3801 sucrose degradation to ethanol and lactate (anaerobic)
BioCyc:TRYPANO_ANARESP1-PWY respiration (anaerobic)
BioCyc:TRYPANO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:LEISH_PWY3IU-61 superpathway of glycolysis, pyruvate dehydrogenase and TCA cycle
BioCyc:TRYPANO_GLYCOLYSIS-E-D superpathway of glycolysis and Entner-Doudoroff
BioCyc:TRYPANO_PWY-5484 glycolysis II
BioCyc:TRYPANO_P122-PWY heterolactic fermentation
BioCyc:TRYPANO_GLUCONEO-PWY gluconeogenesis I
BioCyc:CALBI_GLUCONEO-PWY gluconeogenesis
BioCyc:LEISH_ANARESP1-PWY respiration (anaerobic)
BioCyc:TRYPANO_GLUCARDEG-PWY D-glucarate degradation I
BioCyc:TRYPANO_PWY-1622 formaldehyde assimilation I (serine pathway)
BioCyc:TRYPANO_P124-PWY Bifidobacterium shunt
BioCyc:TRYPANO_PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative)
BioCyc:TRYPANO_GLYCOLYSIS glycolysis I
BioCyc:TRYPANO_GLUCARGALACTSUPER-PWY superpathway of D-glucarate and D-galactarate degradation
BioCyc:TRYPANO_GALACTARDEG-PWY D-galactarate degradation I
View All Pathways