4alpha-hydroxy-tetrahydrobiopterin (BioCAD00000230774)
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Metabolite Card
Formula: C9H15N5O4 (257.1124)
SMILES: CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1
Synonyms [en]
4a-Hthb; 2-amino-6-(1,2-dihydroxypropyl)-4a-hydroxy-5,6,7,8-tetrahydropteridin-4(4aH)-one; 4alpha-hydroxy-tetrahydrobiopterin; 2-amino-6-[(1R,2S)-1,2-Dihydroxypropyl]-4a-hydroxy-1,5,6,7-tetrahydropteridin-4-one; 2-Amino-6-(1,2-dihydroxypropyl)-4a-hydroxy-4a,5,6,7-tetrahydropteridin-4(1H)-one; 4a-Hydroxy-5,6,7,8-tetrahydrobiopterin
Last reviewed on 2024-06-28.
Cite this Page
4alpha-hydroxy-tetrahydrobiopterin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000230774). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
4alpha-hydroxy-tetrahydrobiopterin, also known as 4a-hthb, belongs to biopterins and derivatives class of compounds. Those are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. 4alpha-hydroxy-tetrahydrobiopterin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 4alpha-hydroxy-tetrahydrobiopterin can be found in a number of food items such as garden cress, japanese pumpkin, tronchuda cabbage, and arctic blackberry, which makes 4alpha-hydroxy-tetrahydrobiopterin a potential biomarker for the consumption of these food products. In humans, 4alpha-hydroxy-tetrahydrobiopterin is involved in few metabolic pathways, which include disulfiram action pathway, phenylalanine and tyrosine metabolism, tryptophan metabolism, and tyrosine metabolism. 4alpha-hydroxy-tetrahydrobiopterin is also involved in several metabolic disorders, some of which include hawkinsinuria, monoamine oxidase-a deficiency (MAO-A), phenylketonuria, and tyrosinemia type 3 (TYRO3).
DBLinks
- CAS Registry Number: 70110-58-6
- PubChem CID: 129803
- ChEBI: 15374
- HMDB: HMDB0304198
- LipidMaps:
- KEGG:
- BioCyc:
- NCBI MeSH: 4a-hydroxytetrahydrobiopterin
- Wikipedia:
Other DBLinks
- CAS Registry Number: 70110-58-6
- PubChem: 129803
- PubChem: 135476778
- ChEBI: ChEBI:15374
- HMDB: HMDB0304198
- NCBI MeSH: 4a-hydroxytetrahydrobiopterin
Class / Ontology
- WishartLab ClassyFire: [Pterins and derivatives] Pterins and derivatives
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0120674 | Alkaptonuria |
| PathBank:SMP0120782 | Dopamine beta-Hydroxylase Deficiency |
| PathBank:SMP0120540 | Phenylketonuria |
| PathBank:SMP0000369 | Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) |
| PathBank:SMP0000190 | Hawkinsinuria |
| PathBank:SMP0087330 | Tryptophan Metabolism |
| PathBank:SMP0087450 | Tyrosine Metabolism |
| PathBank:SMP0120729 | Tyrosinemia Type I |
| PathBank:SMP0120733 | Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) |
| PathBank:SMP0120817 | Monoamine Oxidase-A Deficiency (MAO-A) |
| PathBank:SMP0120491 | Hawkinsinuria |
| PathBank:SMP0120511 | Tyrosinemia Type 3 (TYRO3) |
| PathBank:SMP0000206 | Phenylketonuria |
| PathBank:SMP0000169 | Alkaptonuria |
| PathBank:SMP0000429 | Disulfiram Action Pathway |
| PathBank:SMP0087237 | Tryptophan Metabolism |
| PathBank:SMP0087313 | Phenylalanine and Tyrosine Metabolism |
| PathBank:SMP0063684 | Tyrosine Metabolism |
| PathBank:SMP0063693 | Tryptophan Metabolism |
| PathBank:SMP0120760 | Phenylketonuria |