Celastrol (BioCAD00000020180)

plant natural products microbial natural products

Metabolite Card

Formula: C29H38O4 (450.277)
SMILES: [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(O)=O

Synonyms [en]

celastrol; tripterin; tripterine; 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Celastrol. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000020180). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Celastrol, a plant-derived triterpene, has antioxidant and anti-inflammatory activity that may prevent neuronal degeneration in Alzheimer's disease (AD). In the brains of patients with AD signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production. Celastrol suppresses adjuvant arthritis in the rat, demonstrating in vivo anti-inflammatory activity. Low doses of celastrol administered to rats significantly improved their performance in memory, learning and psychomotor activity tests. The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. (PMID: 11513350).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 34157-83-0
  • CAS Registry Number: 34157-83-0 (castrol)
  • CAS Registry Number: 950685-51-5
  • PubChem: 122724
  • ChEBI: ChEBI:63959
  • HMDB: HMDB0002385
  • NCBI MeSH: celastrol
  • Wikipedia: Celastrol
  • RefMet: RM0136187
  • MoNA: Bruker_HCD_library000640
  • MoNA: Bruker_HCD_library001572
  • MoNA: VF-NPL-LTQ006031
  • MoNA: VF-NPL-LTQ006032
  • MoNA: VF-NPL-LTQ006033
  • MoNA: VF-NPL-LTQ006034
  • MoNA: VF-NPL-QEHF002623
  • MoNA: VF-NPL-QEHF002624
  • MoNA: VF-NPL-QEHF002625
  • MoNA: VF-NPL-QEHF002626
  • MoNA: VF-NPL-QEHF002627
  • MoNA: VF-NPL-QEHF002628
  • MoNA: VF-NPL-QEHF002629
  • MoNA: VF-NPL-QEHF002630
  • MoNA: VF-NPL-QEHF002631
  • MoNA: VF-NPL-QEHF002632
  • MoNA: VF-NPL-QEHF002633
  • MoNA: VF-NPL-QEHF002634
  • MoNA: VF-NPL-QTOF007030
  • MoNA: VF-NPL-QTOF007031
  • MoNA: VF-NPL-QTOF007032
  • MoNA: VF-NPL-QTOF007033
  • MoNA: VF-NPL-QTOF007034
  • MoNA: VF-NPL-QTOF007035
  • Metlin: METLIN_43591
  • Coconut NaturalProduct: CNP0199266.2
  • Coconut NaturalProduct: CNP0261301.2
  • Coconut NaturalProduct: CNP0298595.1
  • Coconut NaturalProduct: CNP0298595.2
  • Coconut NaturalProduct: CNP0349338.1

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Angelica keiskei Koidzumi [ncbi taxid: ]
  2. Berberis lambertii [ncbi taxid: ]
  3. Celastraceae [ncbi taxid: 4305]
  4. Celastrus hypoleucus [ncbi taxid: 489980]
  5. Celastrus orbiculatus [ncbi taxid: 85181]
  6. Celastrus paniculatus [ncbi taxid: 994668]
  7. Celastrus scandens [ncbi taxid: 123407]
  8. celastrus strigillosus [ncbi taxid: ]
  9. Centella asiatica [ncbi taxid: 48106]
  10. Crossopetalum gaumeri [ncbi taxid: 1034019]
  11. Echinochloa crus-galli [ncbi taxid: 90397]
  12. Kokoona ochracea [ncbi taxid: 2990840]
  13. Lecanora glaucoma [ncbi taxid: ]
  14. Liatris punctata [ncbi taxid: 344074]
  15. Litsea gracilipes [ncbi taxid: ]
  16. Macrophomina phaseolina [ncbi taxid: 35725]
  17. Maytenus bilocularis [ncbi taxid: ]
  18. Maytenus chuchuhuasca [ncbi taxid: ]
  19. Maytenus ilicifolia [ncbi taxid: ]
  20. Pleurostylia opposita [ncbi taxid: 123450]
  21. Reissantia buchananii [ncbi taxid: 1009587]
  22. Sageretia thea [ncbi taxid: 72166]
  23. Salacia campestris [ncbi taxid: ]
  24. Salacia kraussii [ncbi taxid: 992780]
  25. Sinularia dura [ncbi taxid: ]
  26. Taraxacum borealisinense [ncbi taxid: ]
  27. Taraxacum coreanum [ncbi taxid: 1041103]
  28. Taraxacum mongolicum [ncbi taxid: 90037]
  29. Taraxacum officinale [ncbi taxid: 50225]
  30. Taraxacum platycarpum [ncbi taxid: 170727]
  31. Thunbergia grandiflora [ncbi taxid: 504049]
  32. Trichosanthes kirilowii [ncbi taxid: 3677]
  33. Tripterygium hypoglaucum [ncbi taxid: 205465]
  34. Tripterygium regelii [ncbi taxid: 123485]
  35. Tripterygium wilfordii [ncbi taxid: 458696]
  36. Tripterygium wilfordii Hook f. [ncbi taxid: ]
  37. Zanthoxylum syncarpum [ncbi taxid: 3411617]
  38. Perovskia abrotanoides [ncbi taxid: ]

Pathway Synthetic

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