15H-11,12-EETA (BioCAD00000001969)

{$topic}

Metabolite Card

Formula: C20H32O4 (336.23)
SMILES: CCCCC[C@H](O)\C=C\C1OC1C\C=C/C\C=C/CCCC(O)=O

Synonyms [en]

15H-11,12-EETA; (5Z,8Z,13E)-(15S)-11,12-Epoxy-15-hydroxyicosa-5,8,13-trienoic acid; 11,12-Epoxy-15S-hydroxy-5Z,8Z,13E-eicosatrienoic acid; (5Z,8Z,13E)-(15S)-11,12-Epoxy-15-hydroxyeicosa-5,8,13-trienoic acid; 15-hydroxy-11,12-epoxyeicosatrienoic acid; (+/-)11,12-Ep-15S-HETrE

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

15H-11,12-EETA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000001969). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

15H-11,12-EETA is an epoxyeicosatrienoic acid (EET). The role of EETs in regulation of the cerebral circulation has become more important, since it was realized that EETs are produced in another specialized cell type of the brain, the astrocytes. It has become evident that EETs released from astrocytes may mediate cerebral functional hyperemia. Molecular and pharmacological evidence hve shown that neurotransmitter release and spillover onto astrocytes can generate EETs. Since these EETs may reach the vasculature via astrocyte foot-processes, they have the same potential as their endothelial counterparts to hyperpolarize and dilate cerebral vessels. P450 enzymes contain heme in their catalytic domain and nitric oxide (NO) appears to bind to these heme moieties and block formation of P450 products, including EETs. Thus, there appears to be crosstalk between P450 enzymes and NO/NO synthase. The role of fatty acid metabolites and cerebral blood flow becomes even more complex in light of data demonstrating that cyclooxygenase products can act as substrates for P450 enzymes. (PMID: 17494091, 17468203, 17434916, 17406062, 17361113, 15581597, 11413051, 10519554, 11893556).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 877878-78-9
  • PubChem: 11954042
  • ChEBI: ChEBI:34160
  • HMDB: HMDB0005050
  • LipidMaps: LMFA03080007
  • KEGG: C14781
  • NCBI MeSH: 15-hydroxy-11,12-epoxyeicosatrienoic acid
  • RefMet: RM0153331
  • Metlin: METLIN_36366
  • Coconut NaturalProduct: CNP0153431.1
  • Coconut NaturalProduct: CNP0153431.2
  • Coconut NaturalProduct: CNP0153431.3

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R07042 1.14.14.1 C05966<=>C14781
KEGG:R07044 1.14.14.1 C14781 + C00001<=>C14782
View More
Organism Source

Taxonomy Source

  1. Saprolegnia parasitica [ncbi taxid: 101203]

Pathway Synthetic

pathway id name
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
PathBank:SMP0000692 Antipyrine Action Pathway
PathBank:SMP0000696 Fenoprofen Action Pathway
View All Pathways