THF-L-glutamate (BioCAD00000018459)

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Metabolite Card

Formula: C24H30N8O9 (574.2136)
SMILES: NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1

Synonyms [en]

THF-L-glutamate; Tetrahydrofolyl-[Glu](2); Tetrahydropteroyldiglutamate; 5,6,7,8-tetrahydrofolyl-L-glutamic acid; (6S)-H4PteGlu2; THF-L-Glutamic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

THF-L-glutamate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000018459). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Tetrahydrofolyl-[Glu](n) is involved in the folate biosynthesis pathway. Tetrahydrofolyl-[Glu](n) can be reversibly converted into Tetrahydrofolyl-[Glu](2) by folylpolyglutamate synthase [EC:6.3.2.17]. Tetrahydrofolyl-[Glu](n) can be irreversibly converted into tetrahydrofolate by gamma-glutamyl hydrolase [EC:3.4.19.9].

Entity Information

DBLinks

Other DBLinks
  • PubChem: 442163
  • ChEBI: ChEBI:27650
  • ChEBI: ChEBI:28624
  • HMDB: HMDB0006825
  • HMDB: HMDB06825
  • KEGG: C09332
  • Metlin: METLIN_58560
  • Coconut NaturalProduct: CNP0083994.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00942 6.3.2.17 tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0120742 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000432 Methotrexate Action Pathway
PathBank:SMP0000543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0087196 Folate Metabolism
PathBank:SMP0120656 Folate Malabsorption, Hereditary
PathBank:SMP0087380 Folate Metabolism
PathBank:SMP0120875 Folate Malabsorption, Hereditary
PathBank:SMP0120522 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000053 Folate Metabolism
PathBank:SMP0000724 Folate Malabsorption, Hereditary
PathBank:SMP0000801 Folate Metabolism
PathBank:SMP0087295 Folate Metabolism
PathBank:SMP0087435 Folate Metabolism
View All Pathways