S-(2-Methylpropanoyl)-dihydrolipoamide (BioCAD00000017418)

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Metabolite Card

Formula: C12H23NO2S2 (277.117)
SMILES: CC(C)C(=O)SCCC(S)CCCCC(N)=O

Synonyms [en]

S-(2-Methylpropanoyl)-dihydrolipoamide; S-(2-Methylpropionyl)-dihydrolipoamide-E; S-(2-Methylpropionyl)-dihydrolipoamide; 8-[(2-methylpropanoyl)sulfanyl]-6-sulfanyloctanamide; S-(8-amino-8-oxo-3-sulfanyloctyl) 2-methylpropanethioate; S-(2-Methylpropanoyl)-dihydrolipoamide-e

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

S-(2-Methylpropanoyl)-dihydrolipoamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000017418). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

S-(2-Methylpropionyl)-dihydrolipoamide-E is an intermediate in valine, leucine and isoleucine degradation(KEGG ID C15977). It is the second to last step in the synthesis of branched chain fatty acid and is converted from 2-methyl-1-hydroxypropyl-ThPP via the enzyme 2-oxoisovalerate dehydrogenase [EC:1.2.4.4]. It is then converted to isobutyryl-CoA via the enzyme dihydrolipoyllysine-residue (2-methylpropanoyl)transferase [EC:2.3.1.168].

Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 958734-24-2
  • PubChem: 11953835
  • ChEBI: ChEBI:17577
  • HMDB: HMDB0006868
  • HMDB: HMDB06868
  • LipidMaps: LMFA08010022
  • KEGG: C04424
  • KEGG: C15977
  • BioCyc: CPD-281
  • RefMet: RM0150194
  • Metlin: METLIN_58573
  • Coconut NaturalProduct: CNP0082917.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]

Pathway Synthetic

pathway id name
WikiPathways:WP1451 Valine, leucine and isoleucine degradation
PathBank:SMP0120662 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120806 3-Hydroxyisobutyric Aciduria
PathBank:SMP0120440 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120444 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120516 Maple Syrup Urine Disease
PathBank:SMP0120589 Isovaleric Acidemia
PathBank:SMP0000032 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0000173 beta-Ketothiolase Deficiency
PathBank:SMP0000199 Maple Syrup Urine Disease
PathBank:SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000141 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0000524 Isovaleric Acidemia
PathBank:SMP0087234 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120661 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120665 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120745 Methylmalonic Aciduria
PathBank:SMP0120757 Propionic Acidemia
PathBank:SMP0120805 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0120439 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
View All Pathways