Ribitol (BioCAD00000017279)

blood cerebrospinal fluid (csf) feces urine placenta prostate plant natural products microbial natural products

Metabolite Card

Formula: C5H12O5 (152.0685)
SMILES: OC[C@H](O)[C@H](O)[C@H](O)CO

Synonyms [en]

ribitol; Adonitol; D-Ribitol; L-ribitol; D-Adonitol; Adonite

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Ribitol. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000017279). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Ribitol is a pentose alcohol formed by the reduction of ribose. It occurs naturally in plants as well as in the cell walls of some Gram-positive bacteria. Ribitol forms part of the chemical structure of riboflavin and flavin mononucleotide (FMN). It is also a metabolic end product formed by the reduction of ribose in human fibroblasts and erythrocytes. In this regard ribitol is found in all organisms from bacteria to plants to humans. Ribitol is a normal constituent of human urine (PMID: 2736321). Elevated levels of ribitol in the serum or urine can be found in patients with transaldolase deficiency (PMID: 11283793). Transaldolase is an important enzyme in the pentose phosphate pathway (PPP). Elevated levels of ribitol in the serum or urine can be found in patients with Ribose-5-phosphate isomerase deficiency (PMID: 14988808). Ribose-5-phosphate isomerase is an important enzyme in the pentose phosphate pathway (PPP). Export of ribitol across the cell membrane indicates that can be cleared from the body without metabolic conversion (PMID 15234337). Ribitol is normally absent in Breast milk (PMID 16456418).

Cytoplasm Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 16277-71-7
  • CAS Registry Number: 488-81-3
  • CAS Registry Number: 488-82-4
  • CAS Registry Number: 87-99-0
  • CAS Registry Number: 87849-01-2
  • PubChem: 6912
  • PubChem: 827
  • ChEBI: ChEBI:15963
  • HMDB: HMDB0000508
  • KEGG: C00474
  • BioCyc: RIBITOL
  • Wikipedia: Ribitol
  • RefMet: RM0155896
  • MoNA: BAF_UVA_POS000130
  • MoNA: BAF_UVA_POS000131
  • MoNA: BAF_UVA_POS000132
  • MoNA: CCMSLIB00000479734
  • MoNA: CCMSLIB00005463565
  • MoNA: CCMSLIB00005463582
  • MoNA: CCMSLIB00005720866
  • MoNA: FiehnLib000343
  • MoNA: HMDB0000508_c_ms_1386
  • MoNA: HMDB0000508_ms_ms_725
  • MoNA: HMDB0000508_ms_ms_726
  • MoNA: HMDB0000508_ms_ms_727
  • MoNA: KNA00217
  • MoNA: KNA00218
  • MoNA: KNA00219
  • MoNA: KNA00220
  • MoNA: KNA00451
  • MoNA: KNA00452
  • MoNA: KNA00453
  • MoNA: KNA00454
  • MoNA: KZ000262
  • MoNA: MoNA023845
  • MoNA: MoNA_0006320
  • MoNA: MoNA_0006321
  • MoNA: MoNA_0006322
  • MoNA: MoNA_0006323
  • MoNA: MoNA_0006324
  • MoNA: MoNA_0006325
  • MoNA: MoNA_0006673
  • MoNA: MoNA_0006674
  • MoNA: MoNA_0006675
  • MoNA: MoNA_0006676
  • MoNA: MoNA_0006677
  • MoNA: MoNA_0006679
  • MoNA: MoNA_0007420
  • MoNA: MoNA_0007421
  • MoNA: MoNA_0007422
  • MoNA: MoNA_0007423
  • MoNA: MoNA_0007910
  • MoNA: MoNA_0007911
  • MoNA: MoNA_0008091
  • MoNA: MoNA_0008165
  • MoNA: MoNA_0008166
  • MoNA: MoNA_0008167
  • MoNA: MoNA_0008392
  • MoNA: MoNA_0008393
  • MoNA: MoNA_0008394
  • MoNA: MoNA_0008395
  • MoNA: MoNA_0008396
  • MoNA: MoNA_0008397
  • MoNA: MoNA_0008398
  • MoNA: MoNA_0009735
  • MoNA: MoNA_0009736
  • MoNA: OUF00446
  • MoNA: PR010134
  • MoNA: PR010135
  • MoNA: PS016807
  • Metlin: METLIN_316
  • Coconut NaturalProduct: CNP0264488.1
  • Coconut NaturalProduct: CNP0264488.5

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01732 3.5.99.1 riboflavin hydrolase
KEGG:R01892 1.1.2.2 ribitol:ferricytochrome-c 2-oxidoreductase
KEGG:R01895 1.1.1.56 ribitol:NAD+ 2-oxidoreductase
Rhea:RHEA:11409 3.5.99.1 riboflavin + H2O + H+ => lumichrome + ribitol
Rhea:RHEA:11410 3.5.99.1 lumichrome + ribitol => riboflavin + H2O + H+
Rhea:RHEA:11411 3.5.99.1 riboflavin + H2O + H+ <=> lumichrome + ribitol
Rhea:RHEA:20054 1.1.1.56 ribitol + NAD+ => D-ribulose + NADH + H+
Rhea:RHEA:20055 1.1.1.56 D-ribulose + NADH + H+ => ribitol + NAD+
Rhea:RHEA:20056 1.1.1.56 ribitol + NAD+ <=> D-ribulose + NADH + H+
Rhea:RHEA:47649 D-ribitol 5-phosphate + H2O => ribitol + phosphate
Rhea:RHEA:47650 ribitol + phosphate => D-ribitol 5-phosphate + H2O
Rhea:RHEA:47651 D-ribitol 5-phosphate + H2O <=> ribitol + phosphate
Rhea:RHEA:47653 D-ribitol 1-phosphate + H2O => ribitol + phosphate
Rhea:RHEA:47654 ribitol + phosphate => D-ribitol 1-phosphate + H2O
Rhea:RHEA:47655 D-ribitol 1-phosphate + H2O <=> ribitol + phosphate
BioCyc:RIBOFLAVINASE-RXN 3.5.99.1 PROTON + WATER + RIBOFLAVIN<=>CPD-605 + RIBITOL
BioCyc:RIBITOL-2-DEHYDROGENASE-RXN 1.1.1.56 RIBITOL + NAD<=>D-RIBULOSE + NADH + PROTON
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Organism Source

Taxonomy Source

  1. Anthriscus sylvestris [ncbi taxid: 48027]
  2. Bupleurum chinense [ncbi taxid: 52451]
  3. Bupleurum falcatum [ncbi taxid: 46367]
  4. Bupleurum scorzonerifolium [ncbi taxid: 48105]
  5. Capsella bursa-pastoris [ncbi taxid: 3719]
  6. Daucus carota [ncbi taxid: 4039]
  7. Neopicrorhiza scrophulariiflora [ncbi taxid: 470706]
  8. Picrorhiza kurrooa [ncbi taxid: 195120]
  9. Pogostemon cablin [ncbi taxid: 28511]
  10. Ruta graveolens [ncbi taxid: 37565]
  11. Spinacia oleracea [ncbi taxid: 3562]
  12. Wolfiporia cocos [ncbi taxid: 81056]
  13. Adonis vernalis [ncbi taxid: 46985]
  14. Aesculus turbinata [ncbi taxid: 83375]
  15. Alnus alnobetula [ncbi taxid: 38784]
  16. Anthriscus sylvestris [ncbi taxid: 48027]
  17. Argyreia speciosa [ncbi taxid: ]
  18. Artocarpus styracifolius [ncbi taxid: 1009334]
  19. Bupleurum falcatum [ncbi taxid: 46367]
  20. Capsella bursa [ncbi taxid: ]
  21. Chondodendron toxicoferum [ncbi taxid: ]
  22. Citrus aurantium [ncbi taxid: ]
  23. Curcuma domestica [ncbi taxid: ]
  24. Dacrydium intermedium [ncbi taxid: ]
  25. Daphnia magna [ncbi taxid: 35525]
  26. Dickeya chrysanthemi [ncbi taxid: 556]
  27. Dorstenia mannii [ncbi taxid: 194258]
  28. Eugenia lehmannii [ncbi taxid: ]
  29. Forsythia giraldiana [ncbi taxid: 205689]
  30. Homo sapiens [ncbi taxid: 9606]
  31. Krameria parvifolia [ncbi taxid: ]
  32. Laurencia nidifica [ncbi taxid: 689809]
  33. Lecanora coniza [ncbi taxid: ]
  34. Phyllidiella pustulosa [ncbi taxid: 154616]
  35. Streptomyces griseolus [ncbi taxid: 1909]
  36. Swertia chinensis [ncbi taxid: 149060]
  37. Vernonia profuga [ncbi taxid: 434704]

Pathway Synthetic

pathway id name
BioCyc:META_PWY-5515 L-arabinose degradation II
BioCyc:ECO_DARABCATK12-PWY D-arabinose degradation I
BioCyc:AGRO_RIBITOLUTIL-PWY ribitol degradation
BioCyc:PCHR_RIBITOLUTIL-PWY ribitol degradation
BioCyc:ECOL413997_ARABCAT-PWY L-arabinose degradation I
BioCyc:META_LARABITOLUTIL-PWY xylitol degradation
BioCyc:META_PWY-5525 D-glucuronate degradation I
BioCyc:META_PWY-5257 superpathway of pentose and pentitol degradation
BioCyc:ECO_ARABCAT-PWY L-arabinose degradation I
BioCyc:YEAST_PWY-5516 xylose degradation II
BioCyc:YEAST_LARABITOLUTIL-PWY xylitol degradation
BioCyc:AGRO_LARABITOLUTIL-PWY xylitol degradation
BioCyc:HUMAN_PWY-5525 D-glucuronate degradation
BioCyc:META_ARABCAT-PWY L-arabinose degradation I
BioCyc:META_PWY-5516 D-xylose degradation II
BioCyc:LEISH_LARABITOLUTIL-PWY xylitol degradation
BioCyc:META_RIBITOLUTIL-PWY ribitol degradation
BioCyc:META_DARABCAT-PWY D-arabinose degradation II
BioCyc:META_DARABCATK12-PWY D-arabinose degradation I
PlantCyc:SOY_LARABITOLUTIL-PWY xylitol degradation
View All Pathways