Phloretate (BioCAD00000016200)

blood feces saliva urine kidney liver spleen plant natural products

Metabolite Card

Formula: C9H10O3 (166.063)
SMILES: OC(=O)CCC1=CC=C(O)C=C1

Synonyms [en]

3-(4-hydroxyphenyl)propionic acid; phloretic acid; desaminotyrosine; 3-(4-hydroxyphenyl)propanoic acid; p-Hydroxyhydrocinnamic acid; beta-(p-Hydroxyphenyl)propionic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Phloretate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000016200). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Desaminotyrosine, also known as 4-hydroxyphenylpropionic acid, is a normal constituent of human urine. It is a product of tyrosine metabolism; its concentration in urine increases in patients with gastrointestinal diseases. Desaminotyrosine is a major phenolic acid breakdown product of proanthocyanidin metabolism (PMID:15315398). Urinary desaminotyrosine is produced by Clostridium sporogenes and C. botulinum (PMID:29168502). Desaminotyrosine is also found in Acinetobacter, Bacteroides, Bifidobacteria, Bifidobacterium, Clostridium, Enterococcus, Escherichia, Eubacterium, Klebsiella, Lactobacillus, Pseudomonas, and Staphylococcus (PMID:29168502, 28393285, 19961416). Desaminotyrosine is a phenolic acid metabolite formed by the gut microflora detected after the consumption of whole grain.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 501-97-3
  • PubChem: 10394
  • ChEBI: ChEBI:16331
  • ChEBI: ChEBI:32980
  • HMDB: HMDB0002199
  • HMDB: HMDB02199
  • KEGG: C01744
  • NCBI MeSH: phloretic acid
  • Wikipedia: Phloretic acid
  • Wikipedia: Phloretic_acid
  • DrugBank: DB03897
  • RefMet: RM0050309
  • MoNA: FiehnLib000248
  • MoNA: HMDB0002199_c_ms_99757
  • MoNA: HMDB0002199_c_ms_99758
  • MoNA: HMDB0002199_ms_ms_2025
  • MoNA: HMDB0002199_ms_ms_2026
  • MoNA: HMDB0002199_ms_ms_2027
  • MoNA: JP011626
  • MoNA: KO001096
  • MoNA: KO001097
  • MoNA: KO001098
  • MoNA: KO001099
  • MoNA: KO001100
  • MoNA: MoNA038188
  • MoNA: PS115701
  • Metlin: METLIN_4148
  • Metlin: METLIN_6540
  • Coconut NaturalProduct: CNP0290882.0
  • Coconut NaturalProduct: CNP0583876.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R02901 3.7.1.4 phloretin acylhydrolase (phloroglucinol-forming)
KEGG:R12534 1.3.8.15 phloretate:electron-transfer flavoprotein 2,3-oxidoreductase
Rhea:RHEA:23397 3.7.1.4 phloretin + H2O => phloretate + 1,3,5-trihydroxybenzene + H+
Rhea:RHEA:23398 3.7.1.4 phloretate + 1,3,5-trihydroxybenzene + H+ => phloretin + H2O
Rhea:RHEA:23399 3.7.1.4 phloretin + H2O <=> phloretate + 1,3,5-trihydroxybenzene + H+
Rhea:RHEA:59993 1.3.8.15 phloretate + oxidized [electron-transfer flavoprotein] + H+ => (E)-4-coumarate + reduced [electron-transfer flavoprotein]
Rhea:RHEA:59994 1.3.8.15 (E)-4-coumarate + reduced [electron-transfer flavoprotein] => phloretate + oxidized [electron-transfer flavoprotein] + H+
Rhea:RHEA:59995 1.3.8.15 phloretate + oxidized [electron-transfer flavoprotein] + H+ <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]
Rhea:RHEA:74884 phloretate + S-adenosyl-L-methionine => 3-(4-hydroxyphenyl)propionic acid methyl ether + S-adenosyl-L-homocysteine
Rhea:RHEA:74885 3-(4-hydroxyphenyl)propionic acid methyl ether + S-adenosyl-L-homocysteine => phloretate + S-adenosyl-L-methionine
Rhea:RHEA:74886 phloretate + S-adenosyl-L-methionine <=> 3-(4-hydroxyphenyl)propionic acid methyl ether + S-adenosyl-L-homocysteine
Rhea:RHEA:79508 phloretate + NAD+ => (E)-4-coumarate + NADH + H+
Rhea:RHEA:79509 (E)-4-coumarate + NADH + H+ => phloretate + NAD+
Rhea:RHEA:79510 phloretate + NAD+ <=> (E)-4-coumarate + NADH + H+
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Organism Source

Taxonomy Source

  1. Achlys triphylla [ncbi taxid: 63345]
  2. Acrocarpia paniculata [ncbi taxid: 717668]
  3. Aesculus hippocastanum [ncbi taxid: 43364]
  4. Albizia procera [ncbi taxid: 384949]
  5. Alectoria ochroleuca [ncbi taxid: 111641]
  6. Aloe africana [ncbi taxid: 1080010]
  7. Aloe ferox [ncbi taxid: 117798]
  8. Aloe spicata [ncbi taxid: 992642]
  9. Aloe vera [ncbi taxid: 34199]
  10. Alstonia angustiloba [ncbi taxid: 1504383]
  11. Andrographis viscosula [ncbi taxid: ]
  12. Annona cherimola [ncbi taxid: 49314]
  13. Anodendron affine [ncbi taxid: 582712]
  14. Anthocercis albicans [ncbi taxid: ]
  15. Apis mellifera [ncbi taxid: 7460]
  16. Artemisia giraldii [ncbi taxid: 669123]
  17. Artemisia pectinata [ncbi taxid: ]
  18. Artemisia porrecta [ncbi taxid: 1227638]
  19. Aspergillus microcysticus [ncbi taxid: 176174]
  20. Axinella agnata [ncbi taxid: ]
  21. Baccharis grandicapitulata [ncbi taxid: ]
  22. Bacterium from [ncbi taxid: ]
  23. Beesia calthifolia [ncbi taxid: 78478]
  24. Boschniakia rossica [ncbi taxid: 48555]
  25. Botrychium ternatum [ncbi taxid: 208695]
  26. Bulbophyllum protractum [ncbi taxid: 2487474]
  27. Bursera kerberi [ncbi taxid: 80313]
  28. Bursera tonkinensis [ncbi taxid: 318968]
  29. Calystegia pubescens [ncbi taxid: 649339]
  30. Cedrela salvadorensis [ncbi taxid: 582829]
  31. Chenopodium formosanum [ncbi taxid: 1640932]
  32. Clathria basilana [ncbi taxid: ]
  33. Clerodendrum trichotomum [ncbi taxid: 54229]
  34. Clinacanthus nutans [ncbi taxid: 714457]
  35. Coffea liberica var. dewevrei [ncbi taxid: 213301]
  36. Costasiella ocellifera [ncbi taxid: 380564]
  37. Creosphaeria sassafras [ncbi taxid: 110550]
  38. Crotalaria stolzii [ncbi taxid: 1977610]
  39. Curcuma aeruginosa [ncbi taxid: 136205]
  40. Cypripedium calceolus [ncbi taxid: 53038]
  41. Delisea elegans [ncbi taxid: ]
  42. Delphinium giraldii [ncbi taxid: ]
  43. Diospyros canaliculata [ncbi taxid: 2945278]
  44. Diospyros glaucifolia [ncbi taxid: 413747]
  45. Elymnias thryallis [ncbi taxid: ]
  46. Emericellopsis minima [ncbi taxid: 45245]
  47. Eucalyptus albens [ncbi taxid: 183809]
  48. Euclea crispa [ncbi taxid: 384959]
  49. Euonymus fortunei [ncbi taxid: 255352]
  50. Euploca racemosa [ncbi taxid: 1799586]
  51. Galium verum [ncbi taxid: 462873]
  52. Garcinia cambogia [ncbi taxid: ]
  53. Glycyrrhiza glabra [ncbi taxid: 49827]
  54. Glycyrrhiza inflata [ncbi taxid: 74614]
  55. Glycyrrhiza kansuensis [ncbi taxid: ]
  56. Glycyrrhiza uralensis [ncbi taxid: 74613]
  57. Gutierrezia dracunculoides [ncbi taxid: ]
  58. Hedysarum gmelini [ncbi taxid: ]
  59. Helenium integrifolium [ncbi taxid: ]
  60. Hertia cheirifolia [ncbi taxid: 430993]
  61. Homo sapiens [ncbi taxid: 9606]
  62. Hortonia floribunda [ncbi taxid: 74875]
  63. Iotrochota birotulata [ncbi taxid: 283497]
  64. Juniperus scopulorum [ncbi taxid: 466205]
  65. Lactuca laciniata [ncbi taxid: ]
  66. Lampranthus sociorum [ncbi taxid: 188838]
  67. Lasianthaea podocephala [ncbi taxid: ]
  68. Lentinus tigrinus [ncbi taxid: 5365]
  69. Lepisorus contortus [ncbi taxid: 699669]
  70. Licaria chrysophylla [ncbi taxid: 597316]
  71. Lindera obtusiloba [ncbi taxid: 155295]
  72. Lupinus cosentinii [ncbi taxid: 53222]
  73. Malus pumila [ncbi taxid: 283210]
  74. Malva silvestris [ncbi taxid: ]
  75. Melampodium leucanthum [ncbi taxid: 183048]
  76. Melanargia galathea [ncbi taxid: 111923]
  77. Micromonospora echinospora [ncbi taxid: 1877]
  78. Millettia pinnata [ncbi taxid: ]
  79. Mitracarpus scaber [ncbi taxid: ]
  80. Morella pensylvanica [ncbi taxid: 1155552]
  81. Nauclea rhynchophylla [ncbi taxid: ]
  82. Olea europaea [ncbi taxid: 4146]
  83. Ormosia dasycarpa [ncbi taxid: ]
  84. Ormosia hosiei [ncbi taxid: 1642859]
  85. Ornithoglossum viride [ncbi taxid: 225807]
  86. Papaver pseudocanescens [ncbi taxid: ]
  87. Pellacalyx axillaris [ncbi taxid: 106625]
  88. Penicillium cyclopium [ncbi taxid: 60167]
  89. Persea americana [ncbi taxid: 3435]
  90. Pertusaria amara [ncbi taxid: ]
  91. Pertusaria truncata [ncbi taxid: ]
  92. Perymenium mendezii [ncbi taxid: ]
  93. Pestalotiopsis oenotherae [ncbi taxid: ]
  94. Petasites laevigatus [ncbi taxid: ]
  95. Phlomis crinita [ncbi taxid: 316267]
  96. Picea glauca [ncbi taxid: 3330]
  97. Piper brachystachyum [ncbi taxid: 2974510]
  98. Pocillopora eydouxi [ncbi taxid: ]
  99. Polypodium decumanum [ncbi taxid: ]
  100. Polyscias murrayi [ncbi taxid: 150529]
  101. Pseudocyphellaria australiensis [ncbi taxid: ]
  102. Psidium acutangulum [ncbi taxid: 1835410]
  103. Renealmia alpinia [ncbi taxid: 199658]
  104. Rhododendron mucronulatum [ncbi taxid: 105903]
  105. Rubia tetragona [ncbi taxid: ]
  106. Sarcophyton flexuosum [ncbi taxid: 358802]
  107. Schizanthus tricolor [ncbi taxid: 360636]
  108. Selinum libanotis [ncbi taxid: ]
  109. Senecio congestus [ncbi taxid: ]
  110. Senna spectabilis [ncbi taxid: 347003]
  111. Sideritis dasygnaphala [ncbi taxid: 193331]
  112. Sphaeranthus confertifolius [ncbi taxid: ]
  113. Stellaria media [ncbi taxid: 13274]
  114. Streptomyces melanogenes [ncbi taxid: 67326]
  115. Streptomyces parvisporogenes [ncbi taxid: 68252]
  116. Taraxacum borealisinense [ncbi taxid: ]
  117. Taraxacum coreanum [ncbi taxid: 1041103]
  118. Taraxacum mongolicum [ncbi taxid: 90037]
  119. Taraxacum officinale [ncbi taxid: 50225]
  120. Taraxacum platycarpum [ncbi taxid: 170727]
  121. Tarchonanthus camphoratus [ncbi taxid: 41650]
  122. Tephroseris kirilowii [ncbi taxid: 186974]
  123. Tephrosia purpurea [ncbi taxid: 228354]
  124. Thea sasanqua [ncbi taxid: ]
  125. Tiliacora racemosa [ncbi taxid: ]
  126. Uruparia lanosa [ncbi taxid: ]
  127. Verbascum laxum [ncbi taxid: ]
  128. Zephyranthes flava [ncbi taxid: ]
  129. Bulbine frutescens [ncbi taxid: 210954]

Pathway Synthetic

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