Metabolite Card
Formula: C10H11NO4 (209.0688)
SMILES: OC(=O)CNC(=O)CC1=CC=C(O)C=C1
Synonyms [en]
4-Hydroxyphenylacetylglycine; p-Hydroxyphenylacetylglycine; Hydroxyphenylacetylglycine; N-[(p-hydroxyphenyl)acetyl]-Glycine; [[(4-Hydroxyphenyl)acetyl]amino]acetate; 2-(2-(4-Hydroxyphenyl)acetamido)acetic acid
Last reviewed on 2024-06-28.
Cite this Page
p-Hydroxyphenylacetylglycine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000015775). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Hydroxyphenylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. Hydroxyphenylacetylglycine is an endogenous human metabolite. It can be originated from the metabolism of tyramine, itself is a monoamine compound derived from the amino acid tyrosine. Hydroxyphenylacetylglycine can also be derived from the metabolism of 3,4-dihydroxyphenylalanine (L-DOPA). In the metabolism of tyrosine, this compound is involved in the reaction Hydroxyphenylacetyl-CoA + Glycine <=> Hydroxyphenylacetylglycine + CoA, catalyzed by acyltransferase enzymes (EC 2.3.1.-). Hydroxyphenylacetylglycine has been identified in human biofluids. (PMID: 14201174, 912020, 716472, 7096501, 7438429, 7438430).
DBLinks
- CAS Registry Number: 28116-23-6
- PubChem CID: 440732
- ChEBI: 28595
- HMDB: HMDB0000735
- LipidMaps:
- KEGG: C05596
- BioCyc:
- NCBI MeSH:
- Wikipedia:
Other DBLinks
- CAS Registry Number: 28116-23-6
- PubChem: 440732
- ChEBI: ChEBI:28595
- HMDB: HMDB0000735
- HMDB: HMDB00735
- KEGG: C05596
- RefMet: RM0135984
- MoNA: HMDB0000735_ms_ms_1041
- MoNA: HMDB0000735_ms_ms_1042
- MoNA: HMDB0000735_ms_ms_1043
- Metlin: METLIN_5703
- Coconut NaturalProduct: CNP0084910.0
Class / Ontology
- WishartLab ClassyFire: [Amino acids, peptides, and analogues] Amino acids, peptides, and analogues
- RefMet: [Amino acids] Amino acids
- ChEBI: [CHEBI:28595] 4-hydroxyphenylacetylglycine
- Coconut NaturalProduct: [Dipeptides] Dipeptides