L-Selenocysteine (BioCAD00000013129)

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Metabolite Card

Formula: C3H7NO2Se (168.9642)
SMILES: N[C@@H](C[SeH])C(O)=O

Synonyms [en]

L-Selenocysteine; L-Selenocystein; (2R)-2-amino-3-selanylpropanoic acid; L-Selenozystein; 3-selenyl-L-alanine; Selenocysteine

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

L-Selenocysteine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000013129). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Selenocysteine is an amino acid that is present in several enzymes (for example glutathione peroxidases, tetraiodothyronine 5' deiodinases, thioredoxin reductases, formate dehydrogenases, glycine reductases and some hydrogenases). Selenocysteine has a structure similar to cysteine, but with an atom of selenium taking the place of the usual sulfur. Proteins that include a selenocysteine residue are called selenoproteins (Wikipedia). Selenocysteine is a naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid (Pubchem).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 10236-58-5
  • CAS Registry Number: 3614-08-2
  • PubChem: 25076
  • PubChem: 6326983
  • ChEBI: ChEBI:16633
  • ChEBI: ChEBI:9093
  • HMDB: HMDB0003288
  • KEGG: C05688
  • BioCyc: L-SELENOCYSTEINE
  • Wikipedia: Selenocysteine
  • DrugBank: DB02345
  • RefMet: RM0050436

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03599 4.4.1.16 L-selenocysteine selenide-lyase (L-alanine-forming)
KEGG:R03601 2.5.1.47 O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
KEGG:R04930 4.4.1.1 selenocystathionine lysteine-lyase (deaminating)
KEGG:R04931 2.1.1.9 S-adenosyl-L-methionine:thiol S-methyltransferase
KEGG:R04932 2 C05688<=>C05704
KEGG:R04933 C05688<=>C05705
KEGG:R04934 C05688<=>C05706
KEGG:R04944 2.5.1.48 O-phosphorylhomoserine:selenocysteine Se-(3-amino-3-carboxypropyl)transferase;
KEGG:R04945 2.5.1.48 O-acetylhomoserine succinate-lyase (adding cysteine)
KEGG:R04946 2.5.1.48 O4-succinyl-L-homoserine:L-selenocysteine Se-(3-amino-3-carboxypropyl)transferase;
KEGG:R10430 2.1.1.280 S-methyl-L-methionine:L-selenocysteine Se-methyltransferase
BioCyc:RXN-12726 2.5.1.47 ACETYLSERINE + CPD-678 --> L-SELENOCYSTEINE + ACET + PROTON
BioCyc:SELENOCYSTEINE-LYASE-RXN 4.4.1.16 Donor-H2 + L-SELENOCYSTEINE --> L-ALPHA-ALANINE + SE-2 + Acceptor + 2 PROTON
BioCyc:RXN0-7440 L-SELENOCYSTEINE + Selenocysteine-Lyase-L-Cysteine --> Selenocysteine-Lyase-S-selanyl-L-Cysteine + L-ALPHA-ALANINE
BioCyc:RXN0-7442 4.4.1.16 L-SELENOCYSTEINE + Selenium-Carrier-Protein-L-Cysteine --> L-ALPHA-ALANINE + Selenium-Carrier-Protein-S-selanyl-L-Cysteine
BioCyc:TRANS-RXN0-480 L-SELENOCYSTEINE --> L-SELENOCYSTEINE
BioCyc:RXN-14164 2.1.1.280 CPD-397 + L-SELENOCYSTEINE --> CPD-12024 + MET + PROTON
BioCyc:RXN-11061 2.1.1.280 S-ADENOSYLMETHIONINE + L-SELENOCYSTEINE --> CPD-12024 + ADENOSYL-HOMO-CYS + PROTON
BioCyc:RXN-12728 2.5.1.- L-SELENOCYSTEINE + O-PHOSPHO-L-HOMOSERINE --> Pi + CPD-13717
BioCyc:RXN-15803 CPD-15280 + L-SELENOCYSTEINE + OXYGEN-MOLECULE --> CPD-17044 + WATER
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0087161 Selenoamino Acid Metabolism
PathBank:SMP0087366 Selenoamino Acid Metabolism
PathBank:SMP0087273 Selenoamino Acid Metabolism
PathBank:SMP0063587 Selenoamino Acid Metabolism
PathBank:SMP0000029 Selenoamino Acid Metabolism
PathBank:SMP0002371 Selenocompound Metabolism
PathBank:SMP0087423 Selenoamino Acid Metabolism
View All Pathways