Ibuprofen (BioCAD00000012321)
blood cerebrospinal fluid (csf) urine adipose tissue adrenal cortex adrenal gland bladder epidermis fibroblasts intestine kidney neuron pancreas placenta platelet prostate skeletal muscle spleen testis plant natural products
Metabolite Card
Formula: C13H18O2 (206.1307)
SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
Synonyms [en]
ibuprofen; (RS)-Ibuprofen; Haltran; Ibutid; Anflagen; Nurofen
Last reviewed on 2024-06-28.
Cite this Page
Ibuprofen. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000012321). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. -- Wikipedia.
DBLinks
- CAS Registry Number: 15687-27-1
- PubChem CID: 3672
- ChEBI: 5855
- HMDB: HMDB0001925
- LipidMaps:
- KEGG: C01588
- BioCyc:
- NCBI MeSH: Ibuprofen
- Wikipedia: Ibuprofen
Other DBLinks
- CAS Registry Number: 107010-71-9
- CAS Registry Number: 15687-27-1
- CAS Registry Number: 3674-69-9
- CAS Registry Number: 51146-56-6
- CAS Registry Number: 51146-57-7
- CAS Registry Number: 58560-75-1
- PubChem: 114864
- PubChem: 3672
- PubChem: 39912
- PubChem: 4743
- ChEBI: ChEBI:5855
- HMDB: HMDB0001925
- KEGG: C01588
- KEGG: D00126
- KEGG: D03715
- NCBI MeSH: Ibuprofen
- Wikipedia: Ibuprofen
- DrugBank: DB01050
- RefMet: RM0052815
- MoNA: AU234557
- MoNA: CCMSLIB00000424946
- MoNA: CD_annotated_EnvCpd_suspect_metabolites_NCU_HILIC_NEG000897
- MoNA: CD_annotated_EnvCpd_suspect_metabolites_NCU_RP_NEG000693
- MoNA: EA020301
- MoNA: EA020302
- MoNA: EA020303
- MoNA: EA020304
- MoNA: EA020305
- MoNA: EA020306
- MoNA: EA020307
- MoNA: EA020308
- MoNA: EA020309
- MoNA: EA020310
- MoNA: EA020311
- MoNA: EA020312
- MoNA: EA020314
- MoNA: EA020351
- MoNA: EA020352
- MoNA: EA020358
- MoNA: EA020364
- MoNA: HMDB0001925_ms_ms_1855
- MoNA: HMDB0001925_ms_ms_1856
- MoNA: JP004112
- MoNA: KZ000037
- MoNA: KZ000141
- MoNA: LU128351
- MoNA: LU128352
- MoNA: MoNA035282
- MoNA: MoNA035283
- MoNA: MoNA035286
- MoNA: MoNA038260
- MoNA: PR010166
- MoNA: PS025301
- MoNA: PS025302
- MoNA: WA002724
- MoNA: WA002725
- MoNA: WA002726
- MoNA: WA002727
- Metlin: METLIN_572
- Coconut NaturalProduct: CNP0109383.1
- Coconut NaturalProduct: CNP0241085.0
- Coconut NaturalProduct: CNP0335765.2
Class / Ontology
- WishartLab ClassyFire: [Phenylpropanoic acids] Phenylpropanoic acids
- RefMet: [Cinnamic acids] Cinnamic acids
- ChEBI: [CHEBI:5855] ibuprofen
- Coconut NaturalProduct: [Isocoumarins] Isocoumarins
- Coconut NaturalProduct: [Phenanthrenes] Phenanthrenes
Taxonomy Source
- Artemisia argyi [ncbi taxid: 259893]
- Artemisia montana [ncbi taxid: 669134]
- Artemisia princeps [ncbi taxid: 223870]
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000086 | Ibuprofen Action Pathway |
| PathBank:SMP0000590 | Ibuprofen Metabolism Pathway |