Helichysetin (BioCAD00000119008)

plant natural products microbial natural products

Metabolite Card

Formula: C16H14O5 (286.0841)
SMILES: COC1=C(C(=O)\C=C\C2=CC=C(O)C=C2)C(O)=CC(O)=C1

Synonyms [en]

Helichrysetin; 4,2',4'-Trihydroxy-6'-methoxychalcone; (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Helichysetin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000119008). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Helichrysetin, also known as 2',​4',​4-​trihydroxy-​6'-​methoxychalcone, belongs to the class of organic compounds known as 2'-hydroxychalcones. These are organic compounds containing a chalcone skeleton that carries a hydroxyl group at the 2'-position. Thus, helichrysetin is considered to be a flavonoid lipid molecule. Helichrysetin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. BioTransformer predicts that helichysetin is a product of 2'-O-methylisoliquiritigenin metabolism via a hydroxylation-of-benzene-ortho-to-edg reaction catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223).

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 56121-43-8
  • CAS Registry Number: 62014-87-3
  • PubChem: 6253344
  • ChEBI: ChEBI:178332
  • HMDB: HMDB0132893
  • LipidMaps: LMPK12120300
  • NCBI MeSH: helichrysetin
  • MoNA: Polyphenol000513
  • Metlin: METLIN_52103
  • Coconut NaturalProduct: CNP0195224.0
  • Coconut NaturalProduct: CNP0328235.0

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

  1. Achyrocline flaccida [ncbi taxid: 746492]
  2. Alpinia blepharocalyx [ncbi taxid: 105668]
  3. Amorphophallus konjac [ncbi taxid: 78372]
  4. Aniba santalodora [ncbi taxid: ]
  5. Astragalus circassicus [ncbi taxid: ]
  6. Beilschmiedia madang [ncbi taxid: ]
  7. Bethencourtia palmensis [ncbi taxid: 462391]
  8. Boesenbergia pandurata [ncbi taxid: ]
  9. Boswellia ovalifoliolata [ncbi taxid: 613108]
  10. Campanula choziatowskyi [ncbi taxid: ]
  11. Centaurea scoparia [ncbi taxid: 2072395]
  12. Centaurea sonchifolia [ncbi taxid: ]
  13. Colchicum filifolium [ncbi taxid: 280460]
  14. Cynoglossum macrostylum [ncbi taxid: 1452877]
  15. Dialium excelsum [ncbi taxid: 1608024]
  16. Drymaria cordata [ncbi taxid: 191453]
  17. Dryopteris fragrans [ncbi taxid: 239565]
  18. Dysidea fragilis [ncbi taxid: 1336851]
  19. Epaltes brasiliensis [ncbi taxid: ]
  20. Erythrina hypaphorus [ncbi taxid: ]
  21. Esox lucius [ncbi taxid: 8010]
  22. Etmopterus spinax [ncbi taxid: 648166]
  23. Euphorbia hylonoma [ncbi taxid: 526195]
  24. Gnaphalium affine [ncbi taxid: ]
  25. Goldfussia psilostachys [ncbi taxid: ]
  26. Hardenbergia violacea [ncbi taxid: 53885]
  27. Helichrysum heterolasium [ncbi taxid: 3030090]
  28. Helichrysum odoratissimum [ncbi taxid: 112363]
  29. Heliotropium scabrum [ncbi taxid: ]
  30. Helleborus macranthus [ncbi taxid: ]
  31. Iris kashmiriana [ncbi taxid: ]
  32. Lactarius mitissimus [ncbi taxid: 118866]
  33. Lemonia spectabilis [ncbi taxid: ]
  34. Lepechinia urbanii [ncbi taxid: 1405049]
  35. Lonchocarpus chiricanus [ncbi taxid: 1582177]
  36. Maclura cochinchinensis [ncbi taxid: 194324]
  37. Matricaria sabulosa [ncbi taxid: ]
  38. Matsucoccus josephi [ncbi taxid: ]
  39. Melodorum siamensis [ncbi taxid: ]
  40. Mentzelia decapetala [ncbi taxid: 37834]
  41. Mimosa pigra [ncbi taxid: 367322]
  42. Mucuna holtonii [ncbi taxid: 1127093]
  43. Nepytia freemani [ncbi taxid: 942327]
  44. Orgyia pseudotsugata [ncbi taxid: 33414]
  45. Parmotrema nilgherrense [ncbi taxid: 1450753]
  46. Petunia axillaris subsp. parodii [ncbi taxid: 55890]
  47. Podocarpus dacrydioides [ncbi taxid: ]
  48. Preussia terricola [ncbi taxid: 265085]
  49. Pterocaulon serrulatum [ncbi taxid: 1548653]
  50. Pulsatilla chinensis [ncbi taxid: 714493]
  51. Python molurus [ncbi taxid: 51750]
  52. Quercus marilandica [ncbi taxid: 478951]
  53. Quivisianthe papinae [ncbi taxid: 201287]
  54. Rubia akane [ncbi taxid: ]
  55. Rubus sieboldii [ncbi taxid: 2823971]
  56. Salix rosmarinifolia [ncbi taxid: 2720589]
  57. Salvia lavanduloides [ncbi taxid: 392669]
  58. Salvia patens [ncbi taxid: 392677]
  59. Salvia virgata [ncbi taxid: 1298553]
  60. Senecio platyphylloides [ncbi taxid: ]
  61. Sphaeria rousseliana [ncbi taxid: ]
  62. Thalassiosira weissflogii [ncbi taxid: ]
  63. Dahlia tenuicaulis [ncbi taxid: 101601]
  64. Elsholtzia ciliata [ncbi taxid: 662901]

Pathway Synthetic

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