Erythromycin (BioCAD00000010684)
blood urine plant natural products microbial natural products
Metabolite Card
Formula: C37H67NO13 (733.4612)
SMILES: [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
Synonyms [en]
erythromycin; Erythromycin A; Abomacetin; Erythromycine; Eritromicina; erthromycin
Last reviewed on 2024-06-28.
Cite this Page
Erythromycin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000010684). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Erythromycin belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. Thus, erythromycin is considered to be a macrolide lipid molecule. Erythromycin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with the translocation of amino acids during the translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DBLinks
- CAS Registry Number: 114-07-8
- PubChem CID: 12560
- ChEBI: 42355
- HMDB: HMDB0014344
- LipidMaps: LMPK04000006
- KEGG: C01912
- BioCyc: CPD-13804
- NCBI MeSH: Erythromycin
- Wikipedia: Erythromycin
Other DBLinks
- CAS Registry Number: 114-07-8
- CAS Registry Number: 1675-02-1
- CAS Registry Number: 215031-94-0
- CAS Registry Number: 5442-22-8
- CAS Registry Number: 643-22-1
- CAS Registry Number: 7540-22-9
- CAS Registry Number: 7704-67-8
- CAS Registry Number: 82343-12-2
- PubChem: 12560
- PubChem: 3255
- ChEBI: ChEBI:42355
- HMDB: HMDB0014344
- HMDB: HMDB14344
- LipidMaps: LMPK04000006
- KEGG: C01912
- KEGG: D00140
- BioCyc: CPD-13804
- NCBI MeSH: Erythromycin
- Wikipedia: Erythromycin
- DrugBank: DB00199
- RefMet: RM0138815
- MoNA: AU105401
- MoNA: AU105402
- MoNA: AU105403
- MoNA: AU105404
- MoNA: AU105405
- MoNA: AU105406
- MoNA: AU105407
- MoNA: AU105408
- MoNA: AU105409
- MoNA: AU105410
- MoNA: AU105411
- MoNA: BML81200
- MoNA: BML81201
- MoNA: Bruker_HCD_library000233
- MoNA: Bruker_HCD_library001211
- MoNA: CB000347
- MoNA: CCMSLIB00000075305
- MoNA: CCMSLIB00000075306
- MoNA: CCMSLIB00003739948
- MoNA: CE000001
- MoNA: CE000002
- MoNA: CE000003
- MoNA: CE000004
- MoNA: CE000005
- MoNA: EA018901
- MoNA: EA018902
- MoNA: EA018903
- MoNA: EA018904
- MoNA: EA018905
- MoNA: EA018906
- MoNA: EA018907
- MoNA: EA018908
- MoNA: EA018909
- MoNA: EA018910
- MoNA: EA018911
- MoNA: EA018912
- MoNA: EA018913
- MoNA: EA018914
- MoNA: HMDB0014344_ms_ms_1218314
- MoNA: HMDB0014344_ms_ms_1218315
- MoNA: HMDB0014344_ms_ms_1218316
- MoNA: HMDB0014344_ms_ms_1218317
- MoNA: HMDB0014344_ms_ms_1218318
- MoNA: HMDB0014344_ms_ms_1218319
- MoNA: HMDB0014344_ms_ms_1218320
- MoNA: HMDB0014344_ms_ms_1218321
- MoNA: HMDB0014344_ms_ms_1218322
- MoNA: HMDB0014344_ms_ms_1218323
- MoNA: HMDB0014344_ms_ms_1218324
- MoNA: HMDB0014344_ms_ms_1218325
- MoNA: HMDB0014344_ms_ms_1218326
- MoNA: HMDB0014344_ms_ms_1218327
- MoNA: HMDB0014344_ms_ms_1218328
- MoNA: HMDB0014344_ms_ms_1218329
- MoNA: HMDB0014344_ms_ms_1218330
- MoNA: HMDB0014344_ms_ms_1218331
- MoNA: HMDB0014344_ms_ms_1218332
- MoNA: HMDB0014344_ms_ms_1218333
- MoNA: HMDB0014344_ms_ms_1218334
- MoNA: HMDB0014344_ms_ms_1218335
- MoNA: HMDB0014344_ms_ms_1218336
- MoNA: HMDB0014344_ms_ms_1218337
- MoNA: HMDB0014344_ms_ms_1218338
- MoNA: HMDB0014344_ms_ms_1218339
- MoNA: MoNA001198
- MoNA: MoNA001199
- MoNA: MoNA033252
- MoNA: MoNA033254
- MoNA: MoNA033255
- MoNA: MoNA037571
- MoNA: NGA01645
- MoNA: NGA01646
- MoNA: NGA01647
- MoNA: NGA01648
- MoNA: NGA04305
- MoNA: NGA04306
- MoNA: NGA04307
- MoNA: NGA04308
- MoNA: PB005801
- MoNA: PB005802
- MoNA: PB005803
- MoNA: PB005804
- MoNA: UF407401
- MoNA: UF407402
- MoNA: UF407403
- MoNA: UF407404
- MoNA: VF-NPL-LTQ006443
- MoNA: VF-NPL-LTQ006444
- MoNA: VF-NPL-QEHF003379
- MoNA: VF-NPL-QEHF003380
- MoNA: VF-NPL-QEHF003381
- MoNA: WA002281
- MoNA: WA002282
- MoNA: WA002283
- MoNA: WA002284
- MoNA: WA002285
- MoNA: WA002286
- MoNA: WA002287
- Metlin: METLIN_2573
- Coconut NaturalProduct: CNP0277540.4
- Coconut NaturalProduct: CNP0277540.5
Class / Ontology
- WishartLab ClassyFire: [Carbohydrates and carbohydrate conjugates] Carbohydrates and carbohydrate conjugates
- RefMet: [Macrolides] Macrolides
- LipidMaps: [Macrolides and lactone polyketides [PK04]] Macrolides and lactone polyketides [PK04]
- ChEBI: [CHEBI:42355] erythromycin A
- Coconut NaturalProduct: [Erythromycins] Erythromycins
| ID | EC Number | Name |
|---|---|---|
| KEGG:R05519 | C01912 + C00007<=>C06634 + C00001 | |
| KEGG:R05520 | 2.1.1.254 | S-adenosyl-L-methionine:erythromycin-C 3''-O-methyltransferase |
| KEGG:R05521 | 1.14.13.154 | erythromycin-B,NADPH:oxygen oxidoreductase (12-hydroxylating) |
| BioCyc:RXN-12926 | 1.14.13.154 | CPD-13805 + OXYGEN-MOLECULE + NADPH + PROTON --> CPD-13804 + WATER + NADP |
| BioCyc:RXN-21071 | 3.1.1.- | CPD-13804 + WATER --> CPD-22696 + PROTON |
| BioCyc:RXN-12923 | 2.1.1.254 | S-ADENOSYLMETHIONINE + CPD-13951 --> ADENOSYL-HOMO-CYS + CPD-13804 + PROTON |
Taxonomy Source
- A new engineered strain of Escherichia coli [n.a.] [ncbi taxid: ]
- Bacillus subtilis 1A751-Sfp-nrs [nrs] [ncbi taxid: ]
- Burkholderia pseudomallei 1026b [ncbi taxid: 884204]
- Cassia quinquangulata [ncbi taxid: ]
- Nonomuraea specus [ncbi taxid: ]
- Penicillium camembertii [ncbi taxid: ]
- Penicillium clavigerum [ncbi taxid: 29841]
- Penicillium fuscum [ncbi taxid: 70104]
- Pestalotiopsis humus FKI-7473 [ncbi taxid: ]
- Piper nigrum [ncbi taxid: 13216]
- Pseudoalteromonas sp. [ncbi taxid: 53249]
- Streptomyces [ncbi taxid: 1883]
- Streptomyces AH2 mutant 10/14 [ncbi taxid: ]
- Streptomyces bacillaris strain RAM25C4 [ncbi taxid: ]
- Streptomyces coelicolor [ncbi taxid: 1902]
- Streptomyces enissocaesilis SAS15 [ncbi taxid: ]
- Streptomyces erythraea [ncbi taxid: ]
- Streptomyces erythraea 510 NRRL2338 [ncbi taxid: ]
- Streptomyces fradiae [ncbi taxid: 1906]
- Streptomyces hygroscopicus [ncbi taxid: 1912]
- Streptomyces lasaliensis [ncbi taxid: ]
- Streptomyces lydicus 103 [ncbi taxid: ]
- Streptomyces NRRL 30748 [ncbi taxid: ]
- Streptomyces platensis [ncbi taxid: 58346]
- Streptomyces sp. SAS13 [ncbi taxid: ]
Pathway Synthetic
| pathway id | name |
|---|---|
| WikiPathways:WP2289 | Drug induction of bile acid pathway |
| WikiPathways:WP3253 | Drug induction of bile acid pathway |
| PathBank:SMP0000250 | Erythromycin Action Pathway |