EC: 3.5.2.2

dihydropyrimidinase (5,6-dihydropyrimidine amidohydrolase)

enzyme lambda metabolic reaction experiment
- [dihydropyrimidinase(Enzyme) wildtype]

5,6_Dihydrouracil + H2O -> N_Carbamoyl_beta_alanine		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris/HCl
PH: 7.5
Temperature: 30
- [dihydropyrimidinase(Enzyme) wildtype]

H2O + Hydantoin -> Hydantoic_acid		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris/HCl
PH: 7.5
Temperature: 30
- [dihydropyrimidinase(Enzyme) wildtype]

N_Carbamoyl_beta_alanine -> 5,6_Dihydrouracil + H2O		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Mes/NaOH
PH: 6
Temperature: 30
- [dihydropyrimidinase(Enzyme) wildtype]

Hydantoic_acid -> Hydantoin + H2O		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Mes/NaOH
PH: 6
Temperature: 30
uniprot:Q9I676 [Co2+]

H2O + 5,6_Dihydrouracil -> N_Carbamoyl_beta_alanine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 8
Temperature: 25
uniprot:Q9I676 [Co2+]

H2O + 5_Propylhydantoin -> N_Carbamoylnorvaline		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 8
Temperature: 25
uniprot:Q9I676 [Co2+]

Phthalimide + H2O -> Phthalamic_acid		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 8
Temperature: 25

Pathways

pathway id name
BioCyc:HUMAN_PWY-6430 thymine degradation
BioCyc:META_PWY-6430 thymine degradation
BioCyc:META_PWY-3982 uracil degradation I (reductive)
BioCyc:META_PWY-7209 superpathway of pyrimidine ribonucleosides degradation
BioCyc:MOUSE_PWY-3982 uracil degradation II (reductive)
BioCyc:HUMAN_PWY-7209 pyrimidine ribonucleosides degradation
BioCyc:HUMAN_PWY-3982 uracil degradation
Reactome:R-CEL-73621 Pyrimidine catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-DDI-15869 Nucleotide metabolism
Reactome:R-DDI-8956319 Nucleotide catabolism
Reactome:R-CEL-15869 Nucleotide metabolism
Reactome:R-CEL-8956319 Nucleotide catabolism
Reactome:R-HSA-73621 Pyrimidine catabolism
Reactome:R-MMU-73621 Pyrimidine catabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-73621 Pyrimidine catabolism
Reactome:R-CEL-1430728 Metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-73621 Pyrimidine catabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-8956319 Nucleotide catabolism
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-8956319 Nucleotide catabolism
Reactome:R-RNO-15869 Nucleotide metabolism
Reactome:R-RNO-8956319 Nucleotide catabolism
WikiPathways:WP4584 Biomarkers for pyrimidine metabolism disorders
WikiPathways:WP4225 Pyrimidine metabolism and related diseases
PathBank:SMP0000178 Dihydropyrimidinase Deficiency
PathBank:SMP0000492 Ureidopropionase Deficiency
PathBank:SMP0000046 Pyrimidine Metabolism
PathBank:SMP0000219 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0087473 Pyrimidine Metabolism
PathBank:SMP0000351 GABA-Transaminase Deficiency
PathBank:SMP0000202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0000493 Carnosinuria, Carnosinemia
PathBank:SMP0087432 beta-Alanine Metabolism
PathBank:SMP0000007 beta-Alanine Metabolism
PathBank:SMP0000172 beta-Ureidopropionase Deficiency